Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution.
Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution.
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DOI：
10.1039/c6md00371k
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发表时间：
2016-11-01
期刊：
影响因子：
--
通讯作者：
Bashkin JK
中科院分区：
文献类型：
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作者：
Castaneda CH;Scuderi MJ;Edwards TG;Harris GD Jr;Dupureur CM;Koeller KJ;Fisher C;Bashkin JK
We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC90 values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.
