MT-4 plaque formation can distinguish cytopathic subtypes of the human immunodeficiency virus (HIV).
MT-4 plaque formation can distinguish cytopathic subtypes of the human immunodeficiency virus (HIV).
复制标题
MT-4 斑块形成可以区分人类免疫缺陷病毒 (HIV) 的细胞病变亚型。
DOI：
10.1016/0042-6822(88)90084-0
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发表时间：
1988
期刊：
影响因子：
3.7
通讯作者：
Levy,JA
中科院分区：
文献类型：
--
作者：
Tateno,M;Levy,JA
使用 MT-4 空斑测定，观察了人类免疫缺陷病毒 (HIV) 不同分离株之间空斑形成能力的差异。动力学研究表明，这些差异反映了个体HIV在T细胞中快速复制并引起细胞病变的能力增强。形成斑块的艾滋病病毒全部来自患病患者；健康的血清阳性个体没有携带这些类型的分离株。斑块形成可能是鉴定 HIV 致病株的有用测定方法。
Using the MT-4 plaque assay, differences in the plaque-forming ability among various isolates of the human immunodeficiency virus (HIV) were observed. Kinetic studies showed that these differences reflected the enhanced ability of individual HIV to replicate rapidly in T cells and cause cytopathic changes. The plaque-forming HIV all came from patients with disease; no healthy seropositive individuals had these types of isolates. Plaque formation may be a useful assay for identifying pathogenic strains of HIV.