Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar
Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar
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DOI：
10.1016/j.jgar.2020.02.011
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发表时间：
2020-09-01
影响因子：
4.6
通讯作者：
Tin, Htay Htay
中科院分区：
文献类型：
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作者：
Tada, Tatsuya;Uchida, Hiroki;Tin, Htay Htay
目的：本研究的目的是阐明缅甸医疗机构中多重耐药鲍曼不动杆菌的遗传和流行病学特性。方法：在缅甸医疗机构中共获得45株鲍曼不动杆菌临床分离株。通过下一代测序仪对整个基因组进行测序，并从单核苷酸多态性串联体构建系统发育树。推导多位点序列类型并鉴定耐药基因。结果：从缅甸7家医院获得38株多重耐药鲍曼不动杆菌。大多数 MDR 鲍曼不动杆菌分离株属于 ST2。在38个分离株中，5个含有bla(NDM-1)，28个含有armA或armA2结论：产生16S rRNA甲基化酶ArMA的鲍曼不动杆菌ST2已在缅甸的医疗环境中传播。 (C) 2020 作者。由爱思唯尔有限公司代表国际抗菌化疗协会出版。
Objective: The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar.Methods: A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified.Results: Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored bla(NDM-1), and 28 did armA or armA2Conclusions: A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.