Female infertility, infertility-associated diagnoses, and comorbidities: a review
Female infertility, infertility-associated diagnoses, and comorbidities: a review
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DOI：
10.1007/s10815-016-0836-8
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发表时间：
2017-02-01
影响因子：
3.1
通讯作者：
Hotaling, James
中科院分区：
文献类型：
--
作者：
Hanson, Brent;Johnstone, Erica;Hotaling, James
目的-本研究的目的是评估现有文献的女性不孕症，不孕症相关的诊断，和以下领域的疾病：精神疾病，乳腺癌，卵巢癌，子宫内膜癌，心血管疾病，代谢功能障碍之间的可能关联。方法本研究的设计是一个文献综述。患者是由于诊断为不孕症或与不孕症相关的生殖障碍而纳入26项选定研究的女性。这项研究没有干预措施，和主要的结果措施是女性不孕症或相关的诊断和精神疾病，乳腺癌，卵巢癌，子宫内膜癌，心血管疾病和代谢functions.Results之间的关联女性不孕症和相关的生殖系统疾病可能会产生影响的妇女超越生殖健康。对出版物的分析表明，不孕症妇女的精神疾病和子宫内膜癌发病率高于一般人群[1-10]。关于不孕妇女是否会增加乳腺癌和卵巢癌的风险，数据存在矛盾[7，8，10-20]。不孕症的一般诊断与心血管疾病或代谢功能障碍的风险增加没有明显相关性，但与多囊卵巢综合征（PCOS）相关的不孕症女性确实比普通人群更容易发生心血管疾病和代谢紊乱，如糖尿病[16，21-26]。除了治疗患者的直接生殖需求外，医疗保健专业人员必须了解不孕症的具体原因对健康的更广泛影响，以便提供有关长期风险的准确咨询。
Purpose The purpose of the study is to evaluate existing literature for possible associations between female infertility, infertility-associated diagnoses, and the following areas of disease: psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction.Methods The design of the study is a literature review. The patients were women included in 26 selected studies due to a diagnosis of infertility or a reproductive disorder associated with infertility. This study has no interventions, and the main outcome measure is the association between female infertility or a related diagnosis and psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction.Results Female infertility and related reproductive disorders may have ramifications for women beyond reproductive health. An analysis of publications shows that women with infertility had higher rates of psychiatric disorders and endometrial cancer than the general population [1-10]. Data is conflicting about whether infertile women are at increased risk for breast cancer and ovarian cancer [7, 8, 10-20]. A generalized diagnosis of infertility was not clearly associated with an increased risk of cardiovascular disease or metabolic dysfunction, but women with infertility related to polycystic ovarian syndrome (PCOS) do appear more likely to develop cardio-vascular disease and metabolic disorders such as diabetes than the general population [16, 21-26].Conclusions Female infertility and associated diagnoses have overall health implications. Beyond treatment of patients' immediate reproductive needs, healthcare professionals must be aware of the broader health impact of specific causes of infertility in order to provide accurate counseling regarding long-term risk.