Epidemiological features of parainfluenza virus infections: Laboratory surveillance in England and Wales, 1975-1997
Epidemiological features of parainfluenza virus infections: Laboratory surveillance in England and Wales, 1975-1997
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DOI：
10.1023/a:1007511018330
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发表时间：
1999-05-01
影响因子：
13.6
通讯作者：
Zambon, MC
中科院分区：
文献类型：
--
作者：
Laurichesse, H;Dedman, D;Zambon, MC
对 1975 年至 1997 年间英格兰和威尔士副流感病毒 (PIV) 感染的医院实验室报告进行了 PIV 类型和季节性的分析，此外还分析了 1985 年至 1997 年期间的年龄、性别和临床特征。基于实验室的监测数据突显了不同 PIV 类型的季节性差异。 PIV-3报告显示出明显的年度流行周期，高峰通常出现在春末或夏季，而PIV-1和PIV-2的高峰每隔一年或两年出现在秋末或初冬。 PIV-4也最常在深秋或初冬发生，但无法确定明确的流行周期。实验室监测数据还可以深入了解儿童 PIV 感染的年龄和疾病分布，并表明免疫抑制成人 PIV 感染的严重程度。 1985年至1997年间收到的8221份PIV报告中，PIV-3占70.8份，PIV-1占17.2份，PIV-2占7.5份，PIV-4占1.1份； 64.1 份报告来自一岁以下婴儿，24.4 份来自 1-4 岁儿童，7.2 份来自 5 岁或以上个人，所有年龄组中男性均较多。细支气管炎、哮吼和肺炎的发生与所有 PIV 类型相关。在 1 岁以下儿童中，PIV-2 感染比其他 PIV 类型感染更可能与细支气管炎相关。在 15 岁以下儿童中，哮吼与 PIV-1 和 PIV-2 的相关性高于与 PIV-3 或 PIV-4 的相关性。 1989 年至 1997 年间报告的 PIV 感染中有 392 例 (7.2) 涉及潜在疾病，其中包括免疫抑制或慢性心脏或肺部疾病。婴儿和幼儿的 PIV 感染具有相当大的发病率，因此疫苗的广泛使用将成为一种有价值的公共卫生干预措施。监测信息对于指导预防措施的制定和使用以及监测其有效性至关重要。
Hospital laboratory reports of parainfluenza virus (PIV) infections from England and Wales between 1975 and 1997 were analysed with regard to PIV type and seasonality, and in addition, those between 1985-1997 with regard to age, sex and clinical features. Laboratory-based surveillance data highlight striking differences in the seasonality of different PIV types. PIV-3 reports demonstrated a clear annual epidemic cycle, with a peak usually occurring in late spring or summer, whereas peaks of PIV-1 and PIV-2 occurred at one or two year intervals, in the late autumn or early winter. PIV-4 also occurred most frequently in the late autumn or early winter, but a clear epidemic cycle could not be identified. Laboratory surveillance data also provide insight into the age and disease distribution of PIV infection in children and indicate severity of PIV infection in immunosuppressed adults. Of 8221 PIV reports received between 1985-1997, PIV-3 accounted for 70.8, PIV-1 for 17.2, PIV-2 for 7.5, and PIV-4 for 1.1; 64.1 of reports came from infants under one year, 24.4 from children aged 1-4 years and 7.2 from individuals aged 5 years or older, with an excess of males in all age groups. Bronchiolitis, croup and pneumonia occurred in association with all PIV types. In children under 1 year, PIV-2 infections were more likely to be associated with bronchiolitis than infections with other PIV types. In children under 15 years, croup was more frequently associated with PIV-1 and PIV-2 than with PIV-3 or PIV-4. In 392 (7.2) of the reported PIV infections between 1989 and 1997 an underlying condition was implicated, which included immunosuppression or chronic cardiac or pulmonary disease. Considerable morbidity is associated with PIV infections in infants and young children and would make the widescale use of a vaccine a valuable public health intervention. Surveillance information is essential to guide the development and use of preventive measures as well as to monitor their effectiveness.