The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure.
The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure.
复制标题
去氨加压素对自主神经衰竭患者夜间多尿、夜间体重减轻和早晨体位性低血压的影响。
作者：
C. Mathias;P. Fosbraey;D. Costa;A. Thornley;R. Bannister
对5例未接受药物治疗的慢性自主神经衰竭患者进行昼夜尿量、早晚体重、仰卧位和坐位血压测定。所有患者都有夜间多尿、夜间体重减轻和明显的体位性血压下降，早上血压水平最低。去氨加压素(晚上8点肌肉注射2-4微克)减少了夜间多尿，减少了夜间体重减轻，提高了仰卧位血压，并减少了体位跌倒，特别是在早上，患者往往处于最糟糕的状态。去氨加压素可能是一些自主神经衰竭患者其他形式治疗的有效替代或补充。
Day and night urine volume, morning and evening body weight, and supine and sitting blood pressure were measured in five patients with chronic autonomic failure who were not receiving treatment with drugs. All had nocturnal polyuria, overnight weight loss, and a pronounced postural fall in blood pressure, with lowest levels in the morning. Desmopressin (2-4 micrograms given intramuscularly at 8 pm) reduced nocturnal polyuria, diminished overnight weight loss, raised supine blood pressure, and reduced the postural fall, especially in the morning, when patients were often at their worst. Desmopressin may be a useful alternative to, or may supplement, other forms of treatment in some patients with autonomic failure.