Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea.
Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea.
复制标题
辣椒素敏感迷走神经元参与大鼠气管血管通透性的控制。
DOI：
10.1111/j.1748-1716.1982.tb07116.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
A. Saria
中科院分区：
文献类型：
--
作者：
J. Lundberg;A. Saria
感觉神经元的逆行刺激导致血管扩张(Stricker 1876)和皮肤血管通透性增加(Jancso等人。1976年)。在辣椒素预处理后，这两种作用都被取消(Jancso等人。1967，Lembeck&Holzer 1979)，它导致对化学敏感的初级传入神经元选择性退化(Jancso等人)。1977年)。最近的证据表明，P物质从感觉神经纤维的外周分支释放启动了这些机制(Lembeck&Holzer 1979，Rose11等人)。(1981年)。P物质也定位于呼吸道神经(Nilsson等人)。1977年)和迷走神经的感觉神经元(Lundberg等人。1978年)。本研究旨在了解迷走感觉神经元是否参与了气管粘膜血管通透性的控制。大鼠(体重250-300g)暴露右侧颈迷走神经，切断右侧颈迷走神经，静脉注射溶于生理盐水的伊文思蓝(20mgx kg-L)，5rnin后，切断迷走神经远端。
Antidromic stimulation of sensory neurons leads to vasodilation (Stricker 1876) and increased vascular permeability in the skin (Jancso et al. 1976). Both effects are abolished after capsaicin pretreatment (Jancso et al. 1967, Lembeck & Holzer 1979) which causes selective degeneration of chemosensitive primary afferent neurons (Jancso et al. 1977). Recent evidence suggests that release of substance P from the peripheral branches of sensory nerve fibres is initiating these mechanisms (Lembeck & Holzer 1979, Rose11 et al. 1981). Substance P has also been localized in nerves of the respiratory tract (Nilsson et al. 1977) and in sensory neurons of the vagus nerve (Lundberg et al. 1978). The present studies were performed to see if vagal sensory neurones were involved in the control of vascular permeability in the tracheal mucosa. The right cervical vagus nerve was exposed and cut in rats (b. wt. 250-300 g) anesthetized with Mebumal@(40 mgxkg-'ip). Evans blue (20 mgx kg-l) dissolved in saline was injected into a femoral vein. After 5 rnin, the distal end of the vagus