MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction
MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction
复制标题
用于靶向串联化疗和治疗反应预测的 MRI 引导脂质体
DOI：
10.1016/j.actbio.2016.02.011
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发表时间：
2016-04-15
影响因子：
9.7
通讯作者：
Zhou, Xin
中科院分区：
文献类型：
--
作者：
Ren, Lili;Chen, Shizhen;Zhou, Xin
脂质体是有效的药物输送系统，可以通过成像对比剂功能功能化，从而提供诊断和监测疾病治疗。在这里，我们描述了疗法脂质体药物输送系统的设计，该系统可以通过对比度增强MRI进行实时成像，并可以实现串联化学疗法的药物递送。由于MRI的T-1松弛取决于对比剂的化学结构及其与邻居环境的相互作用，因此我们合理地设计了一种功能性脂质体，用于体内T-1增强MRI。脂质体显示出比商用MRI对比剂Omniscan（R）的T-1松弛率高36倍，并且在体内长达300分钟。此外，多功能脂质体同时携带疏水性和亲水性化学治疗药物，可以协同增强多种药物的治疗作用，并有选择地将其传递到肺部肿瘤中，从而导致较低的剂量，毒性和持续释放。纳米颗粒对肿瘤表现出良好的生物分布，为同时递送多种药物提供了新的可能性，并通过T-1增强的MRI在体内评估治疗反应。在给定疗法中输送单个代理时。两种（或更多）热疗剂的组合提供了一种有希望的方法来规避这种耐药性的情况，这是由于“欺骗”耐药性机制的有利协同作用。关于同时递送疏水和疏水性药物。此外，药物分布的非侵入性体内成像可以实时监测和预测治疗的治疗反应。在这项研究中，我们合理地设计了一种疗法的脂质体药物输送系统，其生物分布可以通过T-1加权MRI成像实时实时，可以实现串联化疗药物的递送。这项原始研究将对更广泛的药物递送社区有很大的用途。 （c）2016 Acta Mitalietia Inc.由Elsevier Ltd.发布的所有权利保留。
Liposomes are effective drug delivery systems that can be functionalized with imaging contrast agents, providing both diagnosis and monitoring of disease treatment. Here we describe the design of a theranostic liposomal drug delivery system whose biodistribution can be real time imaged by contrast enhanced MRI and can achieve tandem chemotherapy drug delivery. Because T-1 relaxation of MRI depends upon the chemical structure of contrast agent as well as its interaction with neighbor environment, we rationally designed a functional liposome for in vivo T-1 enhanced MRI. The liposome shows a 36-fold higher T-1 relaxation rate over the commercial MRI contrast agent Omniscan (R) and a long circulation time up to 300 min in vivo. Moreover, the multifunctional liposome carries both hydrophobic and hydrophilic chemotherapeutic drugs, can synergistically enhance therapeutic effects of multiple drugs and selectively deliver them to lung tumors, leading to lower doses, toxicity and sustained release. The nanoparticles, which exhibit favorable biodistributions to tumors, offer new possibilities for the simultaneous delivery of more than one drug and the evaluation of therapeutic response in vivo by T-1 enhanced MRI.Statement of SignificanceCancer cells invoke different mechanisms to resist cancer therapies, particularly when delivering a single agent in a given therapy. The combination of two (or more) thermotherapy agents provides a promising way to circumvent such situations of drug resistance, due to a favorable synergistic effect that "tricks" the drug resistance mechanism.However, challenges to the simultaneous delivery of two drugs prevail, especially with regards to the simultaneous delivery of hydrophobic and hydrophobic drugs. Furthermore, non-invasive in vivo imaging of drug distribution enables the real-time monitoring and prediction of therapeutic responses to treatment.In this study, we rationally designed a theranostic liposomal drug delivery system whose biodistribution can be imaged via T-1-weighted MRI in real-time and can achieve tandem chemotherapy drug delivery. This original study will be of considerable use to the wider drug delivery community. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.