A new entry in catalytic alkynylation of aldehydes and ketones: dual activation of soft nucleophiles and hard electrophiles by an indium(III) catalyst.
A new entry in catalytic alkynylation of aldehydes and ketones: dual activation of soft nucleophiles and hard electrophiles by an indium(III) catalyst.
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DOI：
10.1021/ol050069h
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发表时间：
2005-03
期刊：
影响因子：
5.2
通讯作者：
Ryo Takita;Y. Fukuta;R. Tsuji;T. Ohshima;M. Shibasaki
中科院分区：
文献类型：
--
作者：
Ryo Takita;Y. Fukuta;R. Tsuji;T. Ohshima;M. Shibasaki
[反应：见原文]羰基化合物催化炔基化的新进展是利用铟（III）催化剂实现软亲核试剂（末端炔）和硬亲电试剂（醛和酮）的双重活化。还讨论了利用原位红外和核磁共振光谱分析进行的初步机理研究。
[reaction: see text] A new entry in catalytic alkynylation of carbonyl compounds was developed in which dual activation of both soft nucleophiles (terminal alkynes) and hard electrophiles (aldehydes and ketones) is achieved using an indium(III) catalyst. Preliminary mechanistic studies using in situ IR and NMR spectroscopic analysis are also discussed.