The Physiological Basis and Clinical Use of the Binaural Interaction Component of the Auditory Brainstem Response.
The Physiological Basis and Clinical Use of the Binaural Interaction Component of the Auditory Brainstem Response.
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DOI：
10.1097/aud.0000000000000301
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发表时间：
2016-09
期刊：
影响因子：
3.7
通讯作者：
Tollin DJ
中科院分区：
文献类型：
--
作者：
Laumen G;Ferber AT;Klump GM;Tollin DJ
听觉脑干反应（ABR）是一种声音诱发的非侵入性测量电位，代表听觉脑干和中脑神经元活动的总和。 ABR 峰值幅度和延迟广泛用于人类和动物听觉研究以及临床筛查。 ABR 的双耳交互分量 (BIC) 代表单耳 ABR 之和与双耳刺激获得的 ABR 之间的差异。 BIC 由一系列不同的波组成，其中最大的波 (DN1) 已用于评估正常听力和听力受损听众的双耳听力。根据动物和人类研究的数据，我们讨论了 BIC（特别是 DN1）可能的解剖学和生理学基础。评估电极放置和刺激特征对双耳诱发 ABR 的影响。我们回顾了耳间时间和强度差异如何影响 BIC，并分析这些依赖性，得出有关 BIC 生成机制的结论。最后总结了BIC在临床诊断中的应用。
The auditory brainstem response (ABR) is a sound-evoked non-invasively measured electrical potential representing the sum of neuronal activity in the auditory brainstem and midbrain. ABR peak amplitudes and latencies are widely used in human and animal auditory research and for clinical screening. The binaural interaction component (BIC) of the ABR stands for the difference between the sum of the monaural ABRs and the ABR obtained with binaural stimulation. The BIC comprises a series of distinct waves, the largest of which (DN1) has been used for evaluating binaural hearing in both normal hearing and hearing-impaired listeners. Based on data from animal and human studies, we discuss the possible anatomical and physiological bases of the BIC (DN1 in particular). The effects of electrode placement and stimulus characteristics on the binaurally evoked ABR are evaluated. We review how inter-aural time and intensity differences affect the BIC and, analyzing these dependencies, draw conclusion about the mechanism underlying the generation of the BIC. Finally, the utility of the BIC for clinical diagnoses are summarized.