Involvement of Noncoding RNAs in Stress-Related Neuropsychiatric Diseases Caused by DOHaD Theory
Involvement of Noncoding RNAs in Stress-Related Neuropsychiatric Diseases Caused by DOHaD Theory
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DOI：
10.1007/978-981-10-5526-3_6
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Kakinuma, Yoshihiko
中科院分区：
文献类型：
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作者：
Nemoto, Takahiro;Kakinuma, Yoshihiko
根据DOHaD的理论，出生体重低是在以后的生活中发展的各种非传染性慢性疾病的风险因素。非编码RNA（ncRNA），包括miRNA、siRNA、piRNA和lncRNA，是从DNA转录但不翻译成蛋白质的功能性RNA分子。通常，miRNA、siRNA和piRNA在转录和转录后水平上起调节基因表达的作用。研究ncRNA为内分泌和代谢领域以及癌症生物学的新诊断和治疗知识提供了机会。在这篇综述中，我们专注于miRNAs和lncRNAs在应激相关神经精神疾病的病理生理学中的作用，这些疾病由于失去反馈控制和/或敏感性降低而显示出异常的血液激素水平。最近的许多研究已经开始揭示ncRNA在调节应激相关激素水平和功能中的重要性。本文基于DOHaD理论，对ncRNA表达异常与应激相关神经精神疾病的关系进行综述。
According to the DOHaD theory, low birth weight is a risk factor for various noncommunicable chronic diseases that develop later in life. Noncoding RNAs (ncRNAs), including miRNAs, siRNAs, piRNAs, and lncRNAs, are functional RNA molecules that are transcribed from DNA but that are not translated into proteins. In general, miRNAs, siRNAs, and piRNAs function to regulate gene expression at the transcriptional and posttranscriptional levels. Studying ncRNAs has provided opportunities for new diagnosis and therapeutic knowledge in the endocrinological and metabolic fields as well as cancer biology. In this review, we focus on the roles of miRNAs and lncRNAs in the pathophysiology of stress-related neuropsychiatric diseases, which show abnormal blood hormone levels due to loss of feedback control and/or decreased sensitivity. Numerous recent studies have begun to unveil the importance of ncRNAs in regulation of stress-related hormone levels and functions. We summarize the involvement of abnormal ncRNA expression in the development of stress-related neuropsychiatric diseases based on the DOHaD theory.