PAROXETINE BINDING IN THE BLOOD-PLATELETS OF POSTTRAUMATIC-STRESS-DISORDER PATIENTS
PAROXETINE BINDING IN THE BLOOD-PLATELETS OF POSTTRAUMATIC-STRESS-DISORDER PATIENTS
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DOI：
10.1016/0024-3205(93)90444-8
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发表时间：
1993-01-01
期刊：
影响因子：
6.1
通讯作者：
CRAYTON, JW
中科院分区：
文献类型：
--
作者：
ARORA, RC;FICHTNER, CG;CRAYTON, JW
通过H-3-帕西汀（PA）结合确定的血小板5-羟色胺（5-HT）摄取在20例创伤后应激障碍（PTSD）患者和20例正常对照组中研究。 k（d）（H-3-Pa结合与摄取位点的亲和力的逆量度）和B（最大）（最大H-3-PA结合位点的最大数量）在PTSD中显着降低患者与正常对照组相比。 但是，在有或没有诊断为严重抑郁症的PTSD患者之间，K（d）或B（max）没有差异。 H-3-Pa结合的B（MAX）与状态依赖焦虑评分负相关，而K（D）与与战斗相关的PTSD评分的密西西比州量表呈正相关。 讨论了血清素能过程在PTSD心理生物学中的作用。
Platelet serotonin (5-HT) uptake, as determined by H-3-paroxetine (PA) binding, was studied in 20 Post-traumatic Stress Disorder (PTSD) patients and 20 normal controls. K(d) (an inverse measure of affinity of H-3-PA binding to uptake sites) and B(max) (maximum number of H-3-PA binding sites) of H-3-PA binding were significantly decreased in PTSD patients as compared to normal controls. However, there was no difference in K(d) or, B(max) between PTSD patients with and without a diagnosis of major depression. The B(max) of H-3-PA binding was negatively correlated with state dependent anxiety score whereas K(d) was positively correlated with the Mississippi Scale for Combat-Related PTSD score. The role of serotonergic processes in the psychobiology of PTSD is discussed.