Anatomical MRI study of basal ganglia in major depressive disorder
Anatomical MRI study of basal ganglia in major depressive disorder
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DOI：
10.1016/s0925-4927(03)00123-9
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发表时间：
2003-11-30
影响因子：
2.3
通讯作者：
Soares, JC
中科院分区：
文献类型：
--
作者：
Lacerda, ALT;Nicoletti, MA;Soares, JC
基底节构成了可能参与情绪调节的脑神经解剖回路的一部分。先前有报道称，与健康对照组相比，重度抑郁症患者的基底节体积减少。在这项研究中，我们使用高分辨率磁共振成像(MRI)测量了25名重度抑郁症患者(4名男性；年龄+/-11岁)和48名健康对照(29名男性；年龄+/-SD=35+/-10岁)的尾状核、壳核和苍白球的体积，试图复制先前的发现。与大多数以前的研究不同，我们没有发现患者组和对照组之间在基底节体积测量方面的显著差异。尽管如此，诊断和大脑半球之间存在显著的交互作用，与健康对照组相比，MDD患者苍白球体积的不对称性降低。此外，在患者组中，左侧壳核体积与病程呈负相关，左侧苍白球体积与既往抑郁发作次数呈正相关。这些发现表明，偏侧化的异常以及可能的基底节结构的神经退行性改变参与了严重抑郁障碍的病理生理学。(C)2003爱思唯尔爱尔兰科学有限公司。保留所有权利。
The basal ganglia form a part of the brain neuroanatomic circuits that may be involved in mood regulation. Decreases in basal ganglia volumes have been previously reported in major depressive disorder patients in comparison to healthy controls. In this study, we measured caudate, putamen, and globus pallidus volumes in 25 patients with major depressive disorder (4 M; age +/- S.D. = 41 +/- 11 years) and 48 healthy controls (29 M; age +/- S.D. = 35 +/- 10 years), using high-resolution magnetic resonance imaging (MRI), in an attempt to replicate prior findings. Unlike most previous studies, we did not find significant differences between patient and control groups in basal ganglia volumetric measures. Nonetheless, there was a significant interaction between diagnosis and cerebral hemisphere, with MDD patients showing decreased asymmetry in globus pallidus volumes in comparison with healthy controls. Furthermore, in the patient group, left putamen volumes correlated inversely with length of illness, and left globus pallidus volume correlated directly with number of prior depressive episodes. These findings suggest that abnormalities in lateralization and possibly neurodegenerative changes in basal ganglia structures participate in the pathophysiology of major depressive disorder. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.