Key factors in mTOR regulation.
Key factors in mTOR regulation.
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DOI：
10.1007/s00018-009-0163-7
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Jiang Y
中科院分区：
文献类型：
--
作者：
Bai X;Jiang Y
哺乳动物雷帕霉素靶蛋白（mTOR）是一种丝氨酸/苏氨酸蛋白激酶，控制着广泛的生长相关细胞过程。在过去的几年中，已经确定了许多参与控制mTOR活性的因素。这些因子反过来又受到响应细胞内和环境条件变化的不同信号级联的调节。mTOR及其调节因子之间的分子连接形成了一个复杂的信号网络，控制细胞代谢、生长和增殖。在这篇综述中，我们讨论了mTOR调节的一些关键因素和这些因素控制mTOR活性的机制。
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a wide range of growth-related cellular processes. In the past several years, many factors have been identified that are involved in controlling mTOR activity. Those factors in turn are regulated by diverse signaling cascades responsive to changes in intracellular and environmental conditions. The molecular connections between mTOR and its regulators form a complex signaling network that governs cellular metabolism, growth and proliferation. In this review, we discuss some key factors in mTOR regulation and mechanisms by which these factors control mTOR activity.