Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy.
Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy.
复制标题
活性氧的双重作用及其在癌症治疗中的应用
DOI：
10.7150/jca.54699
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发表时间：
2021
影响因子：
3.9
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Huang R;Chen H;Liang J;Li Y;Yang J;Luo C;Tang Y;Ding Y;Liu X;Yuan Q;Yu H;Ye Y;Xu W;Xie X
活性氧（ROS）在癌症的发生、发展、抑制和治疗中起着双重作用。过量的活性氧可以诱导核DNA，导致癌症的发生。不仅如此，ROS还能抑制T细胞和自然杀伤细胞，促进巨噬细胞的募集和M2极化；因此，癌细胞逃避免疫监视和免疫防御。此外，ROS通过触发肿瘤细胞的上皮-间质转化来促进肿瘤的侵袭和转移。有趣的是，ROS的大量积累通过两种方式抑制肿瘤生长：(1)通过抑制增殖信号通路、细胞周期以及核苷酸和ATP的生物合成来阻止癌细胞增殖；(2)通过激活内质网应激-、线粒体-、P53-凋亡通路和铁凋亡通路诱导癌细胞死亡。不幸的是，癌细胞可以通过自我适应系统来适应ROS。本文综述了ROS在癌症中的双向调控。本研究进一步探讨了大量积累ROS在癌症治疗中的应用。值得注意的是，预防癌症需要考虑到ROS在癌症中的双重作用和癌细胞的自适应能力。
Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression, and treatment of cancer. Excess ROS can induce nuclear DNA, leading to cancer initiation. Not only that, but ROS also inhibit T cells and natural killer cells and promote the recruitment and M2 polarization of macrophages; consequently, cancer cells escape immune surveillance and immune defense. Furthermore, ROS promote tumor invasion and metastasis by triggering epithelial-mesenchymal transition in tumor cells. Interestingly, massive accumulation of ROS inhibits tumor growth in two ways: (1) by blocking cancer cell proliferation by suppressing the proliferation signaling pathway, cell cycle, and the biosynthesis of nucleotides and ATP and (2) by inducing cancer cell death via activating endoplasmic reticulum stress-, mitochondrial-, and P53- apoptotic pathways and the ferroptosis pathway. Unfortunately, cancer cells can adapt to ROS via a self-adaption system. This review highlighted the bidirectional regulation of ROS in cancer. The study further discussed the application of massively accumulated ROS in cancer treatment. Of note, the dual role of ROS in cancer and the self-adaptive ability of cancer cells should be taken into consideration for cancer prevention.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
9.7
作者：
Azzam EI;Jay-Gerin JP;Pain D
通讯作者：
Pain D
影响因子：
10.1
作者：
Aydin, Ebru;Johansson, Junko;Martner, Anna
通讯作者：
Martner, Anna
影响因子：
56.9
作者：
Cortez, D;Wang, Y;Elledge, SJ
通讯作者：
Elledge, SJ