The relationship between long bone growth rate and duodenal calcium transport in female rats.
The relationship between long bone growth rate and duodenal calcium transport in female rats.
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雌性大鼠长骨生长速率与十二指肠钙转运的关系。
DOI：
10.1002/jbmr.5650030505
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Ibarra,MJ
中科院分区：
文献类型：
--
作者：
Thomas,ML;Hope,WG;Ibarra,MJ
研究了雌性大鼠长骨生长率与十二指肠钙转运的关系以及卵巢激素对这两个参数的调节作用。6周龄雌性大鼠去卵巢(OVX)。在OVX时，一些动物被植入了含有雌二醇或黄体酮的硅橡胶植入物。3周后，当大鼠9周龄时进行研究。OVX使长骨生长速度和十二指肠钙转运增加，而甲状旁腺激素或1，25-二羟基维生素D[1，25-(OH)2D]的循环水平没有任何变化。与去卵巢动物相比，接受雌二醇组动物的长骨生长率和十二指肠钙转运减少。这些动物有轻微的高钙血症，1，25-(OH)2D水平低于OVX或正常动物。这些研究结果表明，卵巢激素状态对十二指肠钙转运的影响与长骨生长速度的关系比与1，25-(OH)2D循环水平的关系更密切。这两个参数是否受到某些未知因素的共同调节，或者骨生长是否能够直接或间接地释放一些信号来增加十二指肠钙的运输，还需要进一步的研究。
Studies were carried out to determine the relationship between long bone growth rate and duodenal calcium (Ca) transport in female rats and the regulation of these two parameters by ovarian hormones. Female rats were ovariectomized (ovx) at 6 weeks of age. Some animals were implanted with silastic implants containing either estradiol or progesterone at the time of ovx. Studies were carried out 3 weeks later when the rats were 9 weeks old. Ovx resulted in an increase in long bone growth rate and duodenal Ca transport without any alteration in circulating levels of parathyroid hormone or 1,25‐dihydroxyvitamin D [1,25‐(OH)2D]. Animals receiving estradiol exhibited decreased long bone growth rate and duodenal Ca transport relative to ovx animals. These animals were mildly hypercalcemic and had lower levels of 1,25‐(OH)2D than ovx or intact animals. The results of these studies suggest that the effects of ovarian hormone status on duodenal Ca transport are more closely related to long bone growth rate than to circulating levels of 1,25‐(OH)2D. Further studies are required to determine whether the two parameters are coregulated by some as‐yet‐unidentified factor or whether bone growth is able to emit some signal, directly or indirectly, to increase duodenal Ca transport.