THE EFFECT OF FRONTAL EYE FIELD AND SUPERIOR COLLICULUS LESIONS ON SACCADIC LATENCIES IN THE RHESUS-MONKEY
THE EFFECT OF FRONTAL EYE FIELD AND SUPERIOR COLLICULUS LESIONS ON SACCADIC LATENCIES IN THE RHESUS-MONKEY
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DOI：
10.1152/jn.1987.57.4.1033
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发表时间：
1987-04-01
影响因子：
2.5
通讯作者：
MAUNSELL, JHR
中科院分区：
文献类型：
--
作者：
SCHILLER, PH;SANDELL, JH;MAUNSELL, JHR
1.恒河猴被训练使用检测和辨别范式对视觉目标进行扫视眼球运动，其中要求它们对单独的刺激（检测）或当该刺激与其他几个刺激同时出现时对该刺激（辨别）进行扫视。2.检测范例产生了一个双峰分布的扫视lavenda与更快的模式峰值约100毫秒（快速扫视），引入之间的停顿终止的固定点和发病的目标（间隙）增加的频率快速扫视。另一方面，即使引入间隙，辨别范式也只产生单峰分布的潜伏期，并且没有短潜伏期“快速”扫视的证据。3.在三只猴子中，无论是额叶的眼睛领域或上级丘消融单侧。在检测或辨别任务中，额叶眼野消融对扫视潜伏期的分布没有明显的长期影响。另一方面，在单侧丘消融后，在检测范例中获得的快速扫视对于病变对侧的眼球运动被消除，只留下单峰分布的lavonis。这种缺陷在整个测试中持续存在，其中一只猴子持续了9个月。对侧眼跳的平均潜伏期比同侧眼跳的第二个峰的平均潜伏期长，对侧眼跳的平均潜伏期比同侧眼跳的第二个峰的平均潜伏期长。与丘病变同侧的眼跳的潜伏期分布不受影响，但手术后几天除外，在此期间，表达眼跳的比例明显增加。4.与歧视范例获得的扫视产生了一个小的，但可靠的增加，在扫视lastness以下丘病变，而不改变形状的分布。5.单侧蝇蕈醇注射到上级丘产生的结果类似于那些获得后立即丘病变：眼跳对侧的注射部位被强烈抑制，并表现出增加眼跳lavage。这是伴随着减少同侧扫视lasting和增加的扫视次数落入表达范围。6.结果表明，上级丘是必不可少的产生的短潜伏期（表达）扫视和额眼场不发挥重要作用，在本研究中使用的范例中的分布的形状扫视lavidae。上级丘似乎也有助于产生较长的潜伏期扫视在检测任务和扫视产生的歧视任务。
1. Rhesus monkeys were trained to make saccadic eye movements to visual targets using detection and discrimination paradigms in which they were required to make a saccade either to a solitary stimulus (detection) or to that same stimulus when it appeared simultaneously with several other stimuli (discrimination). 2. The detection paradigm yielded a bimodal distribution of saccadic latencies with the faster mode peaking around 100 ms (express saccades); the introduction of a pause between the termination of the fixation spot and the onset of the target (gap) increased the frequency of express saccades. The discrimination paradigm, on the other hand, yielded only a unimodal distribution of latencies even when a gap was introduced, and there was no evidence for short-latency "express" saccades. 3. In three monkeys either the frontal eye field or the superior colliculus was ablated unilaterally. Frontal eye field ablation had no discernible long-term effects on the distribution of saccadic latencies in either the detection or discrimination tasks. After unilateral collicular ablation, on the other hand, express saccades obtained in the detection paradigm were eliminated for eye movements contralateral to the lesion, leaving only a unimodal distribution of latencies. This deficit persisted throughout testing, which in one monkey continued for 9 mo. Express saccades were not observed again for saccades contralateral to the lesion, and the mean latency of the contralateral saccades was longer than the mean latency of the second peak for the ipsiversive saccades. The latency distribution of saccades ipsiversive to the collicular lesion was unaffected except for a few days after surgery, during which time an increase in the proportion of express saccades was evident. 4. Saccades obtained with the discrimination paradigm yielded a small but reliable increase in saccadic latencies following collicular lesions, without altering the shape of the distribution. 5. Unilateral muscimol injections into the superior colliculus produced results similar to those obtained immediately after collicular lesions: saccades contralateral to the injection site were strongly inhibited and showed increased saccadic latencies. This was accompanied by a decrease of ipsilateral saccadic latencies and an increase in the number of saccades falling into the express range. 6. The results suggest that the superior colliculus is essential for the generation of short-latency (express) saccades and that the frontal eye fields do not play a significant role in shaping the distribution of saccadic latencies in the paradigms used in this study. The superior colliculus also seems to contribute to the generation of the longer-latency saccades in the detection task and to saccades generated in the discrimination task.