Increased EMG intermuscular coherence and reduced signal complexity in Parkinson's disease
Increased EMG intermuscular coherence and reduced signal complexity in Parkinson's disease
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DOI：
10.1016/j.clinph.2018.10.023
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发表时间：
2019-02-01
影响因子：
4.7
通讯作者：
Lowery, Madeleine M.
中科院分区：
文献类型：
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作者：
Flood, Matthew W.;Jensen, Bente Rona;Lowery, Madeleine M.
目的：为了探讨差异表面肌电图（EMG）功能在个人与特发性帕金森氏病（PD）和年龄匹配controls.Methods：表面肌电图记录在等距腿伸展在PD患者之前，和之后进行的运动训练计划，并在年龄匹配的控制。肌电图结构的差异进行量化使用确定性（%DET），样本熵（SampEn）和肌间coherence.Results：%DET显着较高，和SampEn显着较低，在PD患者。PD组在θ、α和β频段的肌间相干性也显著较高。% DET增加，SampEn下降，增加运动障碍-社会运动障碍评分，而θ波带的连贯性与MDS-MDRS评分和扭矩方差显着相关。无论是%DET，SampEn也不肌间连贯性的变化，响应于training.Conclusions：观察到的差异是一致的运动单位之间的同步性增加和跨腿部肌肉PD。从PD和对照组记录的EMG信号之间的差异持续治疗后，改善行走能力occurrent.Significance：这些结果提供了深入了解运动神经元活动在PD的变化，表现出增加β带肌内的连贯性在PD的第一次，并支持发展的定量生物标志物PD的基础上先进的表面EMG功能。(C)2018国际临床神经生理学联合会。Elsevier B. V.出版，保留所有权利。
Objectives: To investigate differences in surface electromyography (EMG) features in individuals with idiopathic Parkinson's disease (PD) and aged-matched controls.Methods: Surface EMG was recorded during isometric leg extension in PD patients prior to, and after undergoing a locomotor training programme, and in aged-matched controls. Differences in EMG structure were quantified using determinism (%DET), sample entropy (SampEn) and intermuscular coherence.Results: %DET was significantly higher, and SampEn significantly lower, in PD patients. Intermuscular coherence was also significantly higher in the PD group in theta, alpha and beta frequency bands. % DET increased and SampEn decreased with increasing Movement-Disorder-Society UPDRS scores, while theta band coherence was significantly correlated with total MDS-UPDRS scores and torque variance. Neither %DET, SampEn nor intermuscular coherence changed in response to training.Conclusions: The differences observed are consistent with increased synchrony among motor units within and across leg muscles in PD. Differences between EMG signals recorded from the PD and control groups persisted post-therapy, after improvements in walking capacity occurred.Significance: These results provide insight into changes in motoneuron activity in PD, demonstrate increased beta band intramuscular coherence in PD for the first time, and support the development of quantitative biomarkers for PD based on advanced surface EMG features. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.