Genomic regions linked to alcohol consumption in the Framingham Heart Study.
Genomic regions linked to alcohol consumption in the Framingham Heart Study.
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DOI：
10.1186/1471-2156-4-s1-s101
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发表时间：
2003-12-31
期刊：
影响因子：
2.9
通讯作者：
Framingham Heart Study
中科院分区：
文献类型：
--
作者：
Bergen AW;Yang XR;Bai Y;Beerman MB;Goldstein AM;Goldin LR;Framingham Heart Study
在这个以人群为基础的样本中，使用了谱系、人口统计、平方根转换最大酒精摄入量(SRMAXAPD)和最大香烟摄入量(MAXCPD)以及弗雷明翰心脏研究(FHS)的全基因组扫描数据来调查可能影响酒精和香烟消费的遗传因素。显著的姐妹相关：姐妹相关大于配偶相关，仅在MAXCPD中观察到。单点同胞对回归分析为基因座与SRMAXAPD和MAXCPD消费性状的连锁提供了名义上的证据，其中与SRMAXAPD的连锁比与MAXCPD的连锁更显著。基因组区域chr9q21.11表现出显著的多点同胞对回归。与FHS样本中的MAXCPD相比，SRMAXAPD显示了更多的遗传连锁证据。基因组的四个区域在FHS样本中显示了与SRMAXAPD连锁的名义证据，对应于之前在家庭数据集中确定的与酒精中毒或相关特征有关的基因组区域，该家族数据集中确定了受酒精依赖影响的个人，称为COGA。
Pedigree, demographic, square-root transformed maximum alcohol (SRMAXAPD) and maximum cigarette (MAXCPD) consumption, and genome-wide scan data from the Framingham Heart Study (FHS) were used to investigate genetic factors that may affect alcohol and cigarette consumption in this population-based sample. A significant sister:sister correlation greater than spouse correlation was observed for MAXCPD only. Single-point sib-pair regression analysis provided nominal evidence for linkage of loci to both SRMAXAPD and MAXCPD consumption traits, with more significant evidence of linkage to SRMAXAPD than to MAXCPD. One genomic region, chr9q21.11, exhibits significant multi-point sib-pair regression to SRMAXAPD. SRMAXAPD exhibits greater evidence for genetic linkage than does MAXCPD in the FHS sample. Four regions of the genome exhibiting nominal evidence for linkage to SRMAXAPD in the FHS sample correspond to regions of the genome previously identified as linked to alcoholism or related traits in the family data set ascertained on individuals affected with alcohol dependence known as COGA.