Macrophage-inhibitory cytokine-1 (mic-1) in differential diagnosis of dyspnea-A pilot study
Macrophage-inhibitory cytokine-1 (mic-1) in differential diagnosis of dyspnea-A pilot study
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DOI：
10.1016/j.clinbiochem.2009.03.022
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发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Svestak, Marek
中科院分区：
文献类型：
--
作者：
Stejskal, David;Karpisek, Michal;Svestak, Marek
背景资料：巨噬细胞抑制性细胞因子-1（MIC-1）与心功能标志物的关系研究目的：本研究旨在验证心功能标志物（纽约心脏协会分级（NYHA））：左心室射血分数（LVEF）、N末端利钠肽前体B型（NT-proBNP）与MIC-1之间的关系。此外，这些标志物的有用性的鉴别诊断的心肌形式的呼吸困难explored.Methods：124例患者（65名女性和59名男性）进行了检查呼吸困难没有急性冠脉综合征的迹象。所有患者均行超声心动图检查（计算左室射血分数-LVEF），并测定血清NT-proBNP、proguanylin及MIC-1水平。结果和讨论：患者被分为两组：A组为非心源性呼吸困难，n = 77; B组为心源性呼吸困难，n = 47。心源性呼吸困难（中位数2189.6 ng/L）和非心源性呼吸困难（中位数232.1 ng/L）个体的MIC-1值之间存在显著差异。MIC-1与年龄、鸟苷素原、NT-proBNP相关，与LVEF呈负相关（P
Background: Macrophage inhibitory cytokine-1 (MIC-1) has recently been associated with markers of heart function.Aim: This study sought to verify the relationship between markers of heart function (New York Heart Association classification (NYHA)): left ventricle ejection fraction (LVEF), N terminal prohormone of natriuretic peptide B type (NT-proBNP) and MIC-1. Furthermore, the assessment of the usefulness of these markers for differential diagnosis of the myocardial form of dyspnea was explored.Methods: 124 patients (65 women and 59 men) were examined for dyspnea without signs of acute coronary syndrome. All patients underwent echocardiography (calculation of left ventricle ejection fraction-LVEF), and serum NT-proBNP, proguanylin as well as MIC-1 were determined. 21 healthy individuals were defined as the control group.Results and discussion: Patients were divided into two groups: A-individuals with non-cardiogenic form of dyspnea, n = 77 and B individuals with cardiogenic ethiology of dyspnea, n = 47. Significant differences between MIC-1 values in individuals with cardiogenic dyspnea (median 2189.6 ng/L) and non-cardiogenic dyspnea (median 232.1 ng/L) were shown. MIC-1 correlated with age, proguanylin, NT-proBNP and negatively with LVEF (P