Optimal experimental designs for fMRI via circulant biased weighing designs
Optimal experimental designs for fMRI via circulant biased weighing designs
复制标题
通过循环偏置称重设计进行功能磁共振成像的最佳实验设计
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
M. Kao
中科院分区：
文献类型：
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作者：
Ching;M. Kao
功能磁共振成像(FMRI)技术被广泛应用于研究大脑对精神刺激的反应。确定最优的fMRI实验设计对于对大脑功能进行精确的统计推断至关重要，但对这一主题的研究非常缺乏。我们开发了一个通用理论来指导fMRI设计的选择，以估计血液动力学响应函数(HRF)，该函数模拟了精神刺激随时间的影响，并用于研究两种HRF的比较。我们在fMRI设计和循环有偏加权设计之间建立了有用的联系，建立了一些著名的fMRI设计的统计最优性，并识别了几类新的fMRI设计。还给出了高质量fMRI设计的构造方法。
Functional magnetic resonance imaging (fMRI) technology is popularly used in many fields for studying how the brain reacts to mental stimuli. The identification of optimal fMRI experimental designs is crucial for rendering precise statistical inference on brain functions, but research on this topic is very lacking. We develop a general theory to guide the selection of fMRI designs for estimating a hemodynamic response function (HRF) that models the effect over time of the mental stimulus, and for studying the comparison of two HRFs. We provide a useful connection between fMRI designs and circulant biased weighing designs, establish the statistical optimality of some well-known fMRI designs and identify several new classes of fMRI designs. Construction methods of high-quality fMRI designs are also given.