Evaluation of Intracardiac Pressures Using Subharmonic-aided Pressure Estimation with Sonazoid Microbubbles.
Evaluation of Intracardiac Pressures Using Subharmonic-aided Pressure Estimation with Sonazoid Microbubbles.
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使用 Sonazoid 微泡的次谐波辅助压力估计评估心内压力。
DOI：
10.1148/ryct.230153
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Dave,Jaydev
中科院分区：
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作者：
Esposito,Cara;Machado,Priscilla;McDonald,MaureenE;Savage,MichaelP;Fischman,David;Mehrotra,Praveen;Cohen,IraS;Ruggiero2nd,Nicholas;Walinsky,Paul;Vishnevsky,Alec;Dickie,Kristopher;Davis,Marguerite;Forsberg,Flemming;Dave,Jaydev
目的研究是否可以使用采用 Sonazoid 微泡的次谐波辅助压力估计 (SHAPE) 技术无创地获得右心室 (RV) 收缩压和左心室 (LV) 舒张压。材料和方法计划进行左心导管插入术和/或右心导管插入术的个人前瞻性地参加了这项机构审查委员会批准的 2017 年至 2020 年。通过将充满液体的压力导管推进左室和主动脉 (n = 25) 或右室 (n = 22)，并将固态高保真压力导管推进到一部分参与者 (n = 18) 的左室和主动脉，进行标准护理导管插入术。研究参与者接受了 Sonazoid 微泡（GE HealthCare）的输注，并使用在 SonixTablet（BK Medical）美国扫描仪上开发的经过验证的界面获取 SHAPE 数据，与压力导管数据同步。使用 SphygmoCor XCEL PWA (ATCOR) 进行基于袖带的压力测量和来自主动脉的分谐波信号得出转换系数，用于将分谐波信号转换为压力值。比较使用 SHAPE 技术和压力导管获得的压力测量值之间的误差。结果对于 RV，使用 SHAPE 技术获得的压力测量值相对于充满液体的压力导管的压力测量值的平均误差为 1.6 mm Hg ± 1.5 [SD] (P= .85)、8.4 mm Hg ± 6.2 (P= .04) 和 7.4 mm Hg ± 5.7 (P= .09)。 分别为收缩压、左心室最小舒张压和左心室舒张末期压力。相对于固态高保真压力导管的测量，左心室最小舒张压和左心室舒张末压的平均误差分别为 7.2 mm Hg ± 4.5 和 6.8 mm Hg ± 3.3 (P≥ .44)。结论这些结果表明，Sonazoid 的 SHAPE 可能有潜力提供临床相关的 RV 收缩压和 LV 舒张压 关键词：超声造影、心脏、主动脉、左心室、右心室ClinicalTrials.gov 注册号：NCT03245255© RSNA，2024
PurposeTo investigate if the right ventricular (RV) systolic and left ventricular (LV) diastolic pressures can be obtained noninvasively using the subharmonic-aided pressure estimation (SHAPE) technique with Sonazoid microbubbles.Materials and MethodsIndividuals scheduled for a left and/or right heart catheterization were prospectively enrolled in this institutional review board–approved clinical trial from 2017 to 2020. A standard-of-care catheterization procedure was performed by advancing fluid-filled pressure catheters into the LV and aorta (n= 25) or RV (n= 22), and solid-state high-fidelity pressure catheters into the LV and aorta in a subset of participants (n= 18). Study participants received an infusion of Sonazoid microbubbles (GE HealthCare), and SHAPE data were acquired using a validated interface developed on a SonixTablet (BK Medical) US scanner, synchronously with the pressure catheter data. A conversion factor, derived using cuff-based pressure measurements with a SphygmoCor XCEL PWA (ATCOR) and subharmonic signal from the aorta, was used to convert the subharmonic signal into pressure values. Errors between the pressure measurements obtained using the SHAPE technique and pressure catheter were compared.ResultsThe mean errors in pressure measurements obtained with the SHAPE technique relative to those of the fluid-filled pressure catheter were 1.6 mm Hg ± 1.5 [SD] (P= .85), 8.4 mm Hg ± 6.2 (P= .04), and 7.4 mm Hg ± 5.7 (P= .09) for RV systolic, LV minimum diastolic, and LV end-diastolic pressures, respectively. Relative to the measurements with the solid-state high-fidelity pressure catheter, the mean errors in LV minimum diastolic and LV end-diastolic pressures were 7.2 mm Hg ± 4.5 and 6.8 mm Hg ± 3.3 (P≥ .44), respectively.ConclusionThese results indicate that SHAPE with Sonazoid may have the potential to provide clinically relevant RV systolic and LV diastolic pressures.Keywords:Ultrasound-Contrast, Cardiac, Aorta, Left Ventricle, Right VentricleClinicalTrials.gov registration no.: NCT03245255© RSNA, 2024