Progress in the clinical detection of heterogeneity in breast cancer.
Progress in the clinical detection of heterogeneity in breast cancer.
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乳腺癌异质性临床检测进展
DOI：
10.1002/cam4.943
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发表时间：
2016-12
期刊：
影响因子：
4
通讯作者：
Sun SR
中科院分区：
文献类型：
--
作者：
Song JL;Chen C;Yuan JP;Sun SR
乳腺癌是目前最常见的癌症形式，也是女性癌症死亡的第二大原因。尽管乳腺癌的治疗已经取得了相当大的进展，但肿瘤的异质性（肿瘤间和肿瘤内）仍然是一个相当大的诊断和预后挑战。从临床观察到基因突变，了解乳腺癌异质性的历史是漫长而详细的。有效检测乳腺癌的异质性在治疗过程中很重要。描述这种异质性的各种方法现在是可用的，包括遗传学，病理学和成像分析。这些方法允许在基因水平上表征乳腺癌的异质性，在建立有效治疗计划的过程中提供更深入的了解。本研究回顾了对乳腺癌肿瘤异质性的认识，并进一步总结了乳腺癌患者异质性检测和监测的最新进展。
Breast cancer is currently the most common form of cancer and the second‐leading cause of death from cancer in women. Though considerable progress has been made in the treatment of breast cancer, the heterogeneity of tumors (both inter‐ and intratumor) remains a considerable diagnostic and prognostic challenge. From clinical observation to genetic mutations, the history of understanding the heterogeneity of breast cancer is lengthy and detailed. Effectively detecting heterogeneity in breast cancer is important during treatment. Various methods of depicting this heterogeneity are now available and include genetic, pathologic, and imaging analysis. These methods allow characterization of the heterogeneity of breast cancer on a genetic level, providing greater insight during the process of establishing an effective therapeutic plan. This study reviews how the understanding of tumor heterogeneity in breast cancer evolved, and further summarizes recent advances in the detection and monitoring of this heterogeneity in patients with breast cancer.