RETREATMENT WITH THE INDUCTION REGIMEN IN SMALL-CELL LUNG-CANCER RELAPSING AFTER AN INITIAL RESPONSE TO SHORT-TERM CHEMOTHERAPY
RETREATMENT WITH THE INDUCTION REGIMEN IN SMALL-CELL LUNG-CANCER RELAPSING AFTER AN INITIAL RESPONSE TO SHORT-TERM CHEMOTHERAPY
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DOI：
10.1016/0277-5379(87)90128-3
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发表时间：
1987-09-01
期刊：
影响因子：
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通讯作者：
BAKKER, W
中科院分区：
文献类型：
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作者：
POSTMUS, PE;BERENDSEN, HH;BAKKER, W
在37例小细胞肺癌患者中，用环磷酰胺、阿霉素和依托泊苷（CDE）治疗5个周期，导致23例完全缓解（CR）和14例部分缓解（PR）。中位缓解持续时间为34周。复发时，所有患者均接受CDE复治。在23例（62%）患者中，这产生了第二次缓解（6例CR，17例PR）。影响第二次反应发生的因素有：1。CDE前5个周期后CR者23例，CR者18例，PR者14例，PR者5例（P < 0.01）。2.首次缓解时间> 34周的19例患者中有15例达到二次缓解，其余18例患者中有8例复治成功（P < 0.05）。在复发时，在短期化疗和无治疗间隔后，使用诱导方案进行再诱导是初始CR和首次缓解持续时间< 34周的患者的有效二线治疗。
In 37 patients with small cell lung cancer treatment with five cycles of cyclophosphamide, doxorubicin and etoposide (CDE), resulted in 23 complete (CR) and 14 partial responses (PR). Median response duration was 34 weeks. At relapse all patients were retreated with CDE. In 23 (62%) patients this gave a second response (6 CR, 17 PR). Factors influencing the occurrence of a second response were: 1. a CR after the first five cycles of CDE; 18 out of 23 CR patients responded again whereas only five of the 14 PR patients responded (P < 0.01). 2. 15 out of 19 patients with a first response duration > 34 weeks reached a second response and in eight of the other 18 patients retreatment was successful (P < 0.05). Reinduction at relapse, after short term chemotherapy and a treatment-free interval, with the induction regimen is an effective second line treatment in patients with an initial CR and a first response duration of < 34 weeks.