DNA-based supramolecular hydrogels: From construction strategies to biomedical applications
DNA-based supramolecular hydrogels: From construction strategies to biomedical applications
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DOI：
10.1016/j.cclet.2023.108627
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发表时间：
2023-09-06
影响因子：
9.1
通讯作者：
Liu，Huajie
中科院分区：
文献类型：
--
作者：
Chen，Ping;Yu，Chenhong;Liu，Huajie
基于DNA的超分子水凝胶由于其固有的生物相容性和可调的物理化学性质而成为重要的和有前途的生物材料。通过非共价动态交联形成的DNA的三维超分子基质为水凝胶提供了优异的适应性、自修复、可注射和响应性。此外，DNA水凝胶由于其组织样的力学性质和内在的生物功能，也是理想的生物支架材料。从技术上讲，DNA可以通过纯粹的互补碱基配对组装成超分子网络;它也可以与其他构建块组合以构建混合水凝胶。本文综述了DNA水凝胶的发展和构建策略。综述了组装与合成方法、多样的响应性和生物医学应用。最后，对DNA基超分子水凝胶的发展前景进行了展望。
DNA-based supramolecular hydrogels are important and promising biomaterials for various applications due to their inherent biocompatibility and tunable physicochemical properties. The three-dimensional supramolecular matrix of DNA formed by non-covalently dynamic cross-linking provides exceptional adaptability, self-healing, injectable and responsive properties for hydrogels. In addition, DNA hydrogels are also ideal bio-scaffold materials owing to their tissue-like mechanics and intrinsic biological functions. Technically, DNA can assemble into supramolecular networks by pure complementary base pairing; it can also be combined with other building blocks to construct hybrid hydrogels. This review focuses on the development and construction strategies of DNA hydrogels. Assembly and synthesis methods, diverse responsiveness and biomedical applications are summarized. Finally, the challenges and prospects of DNA-based supramolecular hydrogels are discussed.