From observation to experimentation: leptin action in the mediobasal hypothalamus.
From observation to experimentation: leptin action in the mediobasal hypothalamus.
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DOI：
10.3945/ajcn.2008.26788d
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发表时间：
2009-03
期刊：
影响因子：
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通讯作者：
K. Williams;Michael M. Scott;J. Elmquist
中科院分区：
文献类型：
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作者：
K. Williams;Michael M. Scott;J. Elmquist
迅速发展的肥胖流行病推动了从机制上描述代谢稳态的动力。从早期的理论暗示葡萄糖作为主要的调节剂增长的理解的复杂阵列的代谢信号，感觉周围器官沿着与中枢神经系统（CNS）内的特定位置。瘦素是一种脂肪源性激素，它在下丘脑内侧基底部起作用，控制食物摄入和能量消耗，这一发现引发了长达十年的研究，这些研究不仅描述了特定的核和细胞类型，如弓状核的阿黑皮素原神经元，它们对瘦素有反应，而且还描述了介导瘦素效应的信号级联。因此，这篇综述突出了瘦素的作用的网站和机制，无论是在下丘脑和下丘脑外的网站在中枢神经系统内，并显示我们目前的知识和未来的研究方向，旨在了解瘦素在维持代谢稳态的多功能作用。
The burgeoning obesity epidemic has fueled the drive to describe, mechanistically, metabolic homeostasis. From the early theories implicating glucose as a principal modulator grew an understanding of a complex array of metabolic signals, sensed by peripheral organs along with specific locations within the central nervous system (CNS). The discovery that leptin, an adipose-derived hormone, acts within the mediobasal hypothalamus to control food intake and energy expenditure ushered in a decade of research that went on to describe not only the specific nuclei and cell type, such as proopiomelanocortin neurons of the arcuate nucleus, that respond to leptin but also the signaling cascades that mediated its effects. This review thus highlights the sites and mechanisms of action of leptin, both in the hypothalamus and in extrahypothalamic sites within the CNS, and shows our current knowledge and direction of future research aimed at understanding the multifunctional role of leptin in maintaining metabolic homeostasis.