Toxic neuropathies.
Toxic neuropathies.
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中毒性神经病。
DOI：
10.1097/00019052-199510000-00008
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发表时间：
1995
影响因子：
4.8
通讯作者：
Powell,HC
中科院分区：
文献类型：
--
作者：
Mizisin,AP;Powell,HC
目前的出版物描述了金属、医药产品以及环境、生物和实验物质的神经毒性效应。铅等毒剂仍然是确定受害者身份的新流行病学方法的对象。正在探索使用甲钴胺来减轻丙烯酰胺的毒性。抗心律失常和降血脂药物仍然与神经病变作用有关，但似乎可以调整剂量。为了帮助控制化疗药物的神经毒性作用，正在使用促肾上腺皮质激素和神经营养因子的紫杉醇和顺铂类似物。一种新的免疫抑制剂FK 506已经取代了环孢素来促进器官移植，但在一些患者中已经记录了包括周围神经病变在内的不良反应。在实验研究中，有报道称FK 506可以加快神经再生的速度。肉毒杆菌毒素用于治疗局限性痉挛障碍是一种有效的治疗方法，但美国神经病学学会建议进行培训和监督。实验毒素，如亚氨基二丙腈，继续为生理机制提供有用的见解，包括细胞骨架组件的轴突运输。
Current publications describe neurotoxic effects of metals, pharmaceutical products, and environmental, biological and experimental substances. Agents such as lead remain the object of new epidemiological methods to identify victims. The use of methylcobalamin to ameliorate acrylamide toxicity is being explored. Antiarrhythmic and antilipidemic drugs continue to be associated with neuropathic effects but appear to be amenable to adjustments in dosage. To help control the neurotoxic effects of the chemotherapeutic drugs taxol and cisplatin analogs of adrenocorticotropic hormone and neurotrophic factors are being used. A new immunosuppressant, FK 506, has replaced cyclosporin to facilitate organ transplantation, but unwanted effects, including peripheral neuropathy, have been documented in some patients. In experimental studies, FK 506 has been reported to accelerate the rate of nerve regeneration. Botulinum toxin for the treatment of localized spastic disorders is a useful therapy, but training and supervision has been recommended by the American Academy of Neurology. Experimental toxins, such as imminodipropionitrile, continue to provide useful insights into physiologic mechanisms, including the axonal transport of cytoskeletal components.