Emergence of Polymer Stereocomplexes for Biomedical Applications
Emergence of Polymer Stereocomplexes for Biomedical Applications
复制标题
DOI：
10.1002/macp.201200143
复制
发表时间：
2012-11-23
影响因子：
2.5
通讯作者：
Bertin, Annabelle
中科院分区：
文献类型：
--
作者：
Bertin, Annabelle
几十年来，聚丙交酯 (PLA) 和聚甲基丙烯酸甲酯 (PMMA) 因其生物相容性/惰性而成为各种生物医学应用的黄金标准。此外，它们还有一个额外的特性：它们可以形成立体复合物（SC），其晶体结构比单个组分更紧凑。因此，在基于 PLA 的药物输送系统和生物材料中，聚合物 SC 表现出改善的热性能和机械性能，以及延迟的药物释放和生物降解率，这在生物医学领域至关重要。在本文中，强调了 SC 在药物输送、组织工程和纳米结构表面领域的生物医学应用潜力。
Polylactide (PLA) and poly(methyl methacrylate) (PMMA) constitute, already for several decades, the gold standards for various biomedical applications due to their biocompatibility/inertness. Moreover, they have an additional property: they can form stereocomplexes (SCs) that have a more compact crystalline structure than the individual components. As a result, polymer SCs display improved thermal and mechanical properties, as well as delayed drug release and biodegradation rate in the case of drug delivery systems and biomaterials based on PLA, which is of prime importance in the biomedical field. In this article, the potential of SCs for biomedical applications in the areas of drug delivery, tissue engineering, and nanostructured surfaces is highlighted.