DURATION EFFECT OF OBSESSIVE-COMPULSIVE DISORDER ON COGNITIVE FUNCTION: A FUNCTIONAL MRI STUDY
DURATION EFFECT OF OBSESSIVE-COMPULSIVE DISORDER ON COGNITIVE FUNCTION: A FUNCTIONAL MRI STUDY
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DOI：
10.1002/da.20484
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发表时间：
2009-09-01
影响因子：
7.4
通讯作者：
Kanba, Shigenobu
中科院分区：
文献类型：
--
作者：
Nakao, Tomohiro;Nakagawa, Akiko;Kanba, Shigenobu
背景：先前检查强迫症（OCD）认知功能的报告的不一致表明其异质性。在这项研究中，我们研究了疾病持续时间对强迫症患者认知功能的影响。方法：我们通过神经心理学测试和功能性磁共振成像检查了 32 名强迫症患者和 16 名健康志愿者的认知功能，同时他们执行 Stroop 和 N-back 任务以评估注意力和非语言记忆。根据病程将患者分为两组：短期组（n = 17，5.5 +/- 3.1 年）和长期组（n = 15，20.3 +/- 6.1 年）。进行统计分析以确定这两组与正常对照组（n = 16）之间的差异。结果：长期组在神经心理学测试中表现出注意力缺陷和非语言记忆功能障碍。相比之下，在功能磁共振成像中，与长期组和正常对照组相比，短期组在 Stroop 任务中表现出较弱的右侧尾状核激活，在 N-back 任务中表现出较强的右侧背外侧前额叶皮层激活。结论：结果表明，强迫症的早期阶段会出现大脑异常激活，强迫症的长期持续存在可能会导致认知功能下降。抑郁与焦虑 26:814-823, 2009。(C) 2008 Wiley-Liss, Inc.
Background: The inconsistency of previous reports examining cognitive function in obsessive-compulsive disorder (OCD) suggests its heterogeneity. In this study, we examined the effect of illness duration on cognitive function in OCD. Methods: We examined the cognitive function of 32 OCD patients and 16 healthy volunteers by neuropsychological tests and functional magnetic resonance imaging while they performed the Stroop and N-back tasks to assess attention and nonverbal memory. The patients were divided into two groups by illness duration: a short-term group (n = 17, 5.5 +/- 3.1 years) and a long-term group (n = 15, 20.3 +/- 6.1 years). Statistical analysis was performed to determine the differences between these two groups and the normal control group (n = 16). Results: The long-term group showed attention deficit and nonverbal memory dysfunction on the neuropsychological tests. In contrast, on functional magnetic resonance imaging, the short-term group showed weaker activation of the right caudate during the Stroop task and stronger activation of the right dorso-lateral prefrontal cortex during the N-back task than the long-term and normal control groups. Conclusions: The results suggested that abnormal brain activation occurs in the early phase of OCD and that the long-term persistence of OCD might involve a decline in cognitive function. Depression and Anxiety 26:814-823, 2009. (C) 2008 Wiley-Liss, Inc.