Crossing the line: selection and evolution of virulence traits.
Crossing the line: selection and evolution of virulence traits.
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DOI：
10.1371/journal.ppat.0020042
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发表时间：
2006-05
期刊：
影响因子：
6.7
通讯作者：
Finlay BB
中科院分区：
文献类型：
--
作者：
Brown NF;Wickham ME;Coombes BK;Finlay BB
病原体的进化呈现出一种悖论。在进化过程中，病原物种通常绝对依赖于寄主物种进行繁殖，但病原生活方式要求寄主在这种依赖过程中受到损害。很明显，致病策略在进化方面是成功的，因为自然界中存在着各种各样的病原体。病原体也利用广泛的分子机制进化，以获得和调节现有的毒力特征，以实现这一成功。详细说明通过毒力产生的强化选择的好处，并了解毒力进化的机制对于理解自然界很重要，两者都对人类健康有影响。
The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle requires that the host be damaged during this dependence. It is clear that pathogenic strategies are successful in evolutionary terms because a diverse array of pathogens exists in nature. Pathogens also evolve using a broad range of molecular mechanisms to acquire and modulate existing virulence traits in order to achieve this success. Detailing the benefit of enhanced selection derived through virulence and understanding the mechanisms through which virulence evolves are important to understanding the natural world and both have implications for human health.