ORGAN EQUIVALENT DOSE AND LIFETIME ATTRIBUTABLE RISK OF CANCER INCIDENCE AND MORTALITY ASSOCIATED WITH CARDIAC CT ANGIOGRAPHY
ORGAN EQUIVALENT DOSE AND LIFETIME ATTRIBUTABLE RISK OF CANCER INCIDENCE AND MORTALITY ASSOCIATED WITH CARDIAC CT ANGIOGRAPHY
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DOI：
10.1093/rpd/ncaa033
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发表时间：
2020-04-01
影响因子：
1
通讯作者：
Feyzabad, Seyed Hasan Fatehi
中科院分区：
文献类型：
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作者：
Nasab, Seyed Mohammad Bagher Hosseini;Deevband, Mohammad Reza;Feyzabad, Seyed Hasan Fatehi
本研究的目的是计算等效器官剂量，并估计与心脏计算机断层血管造影（CCTA）相关的癌症发病率和死亡率的终生归因风险（LAR），因为CT血管造影作为一种无创诊断方法的使用越来越多。器官剂量由ImPACT软件根据体积CT剂量指数（CTDIvol）计算，CCTA癌症风险发生率和死亡率的LAR根据BEIR VII报告估计。男女有效剂量中位数为13.78±6.88 mSv。在所有扫描仪中，男性和女性肺癌LAR发病率的最高中位数分别为44.20和109.17 / 10万。婴儿中男性肺癌和女性乳腺癌的患病率分别为5.89和12。此外，男性和女性成年患者单次CCTA的所有癌症发病率的LAR中位数分别为122和238例。成人肺癌死亡率的最大LAR分别为40.28和91.84，儿科的最大LAR分别为5.69和8.50。尽管CTA在心脏病评估中有许多好处，但根据CCTA的高辐射剂量，以降低癌症风险：CCTA应谨慎使用，特别是对儿童和女性。
The aim of this study is the calculation of equivalent organ dose and estimation of lifetime attributable risk (LAR) of cancer incidence and mortality related to cardiac computed tomography angiography (CCTA) because the use of CT angiography as a noninvasive diagnostic method has increased. The organ dose has been calculated by ImPACT software based on the volumetric CT dose index (CTDIvol), and LAR of cancer risk incidence and mortality from CCTA has estimated according to the BEIR VII report. The median value of the effective dose was 13.78 +/- 6.88 mSv for both genders. In all scanners, the highest median value for LAR of cancer incidence in males and females for lung cancer was 44.20 and 109.17 per 100 000, respectively. And in infants was 5.89 and 12 for lung cancer in males and breast cancer in females, respectively. Also, the median value of LAR of all cancer incidence from single CCTA in adult patients for males and females was 122 and 238 cases, respectively. Maximum LAR of cancer mortality in adults for lung cancer was 40.28 and 91.84 and in pediatrics was 5.69 and 8.50 in males and females, respectively. Despite many benefits of CTA in the heart disease evaluation, according to a high radiation dose in CCTA, to reduce the cancer risk: CCTA should be used cautiously, especially for pediatric and females.