The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis.
The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis.
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二甲双胍对胰腺癌患者生存的影响：荟萃分析。
DOI：
10.1038/s41598-017-06207-x
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发表时间：
2017-07-19
影响因子：
4.6
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Li X;Li T;Liu Z;Gou S;Wang C
我们进行了一项荟萃分析，分析二甲双胍对不同阶段胰腺癌患者生存率的影响。我们对PubMed、Embase、科克伦和Web of Science进行了系统检索，以确定所有相关研究。根据研究间异质性，采用固定或随机效应模型计算生存期的汇总风险比（HR）和95%置信区间（95% CI）。9项回顾性队列研究和2项随机对照试验（RCT）符合条件。与对照组相比，二甲双胍组的生存率显著改善（HR = 0.86，95%CI 0.76-0.97; P < 0.05）。亚组分析表明二甲双胍改善了切除患者的生存率（HR = 0.79，95%CI 0.69-0.91; P < 0.05）和局部晚期肿瘤患者（HR = 0.68，95%CI 0.55-0.84; P < 0.05），但即使纳入RCT数据，转移性肿瘤患者的情况也是如此（HR = 0.99，95% CI 0.70-1.40; P > 0.05）或排除（HR = 0.89，95% CI 0.61-1.31; P > 0.05）。该荟萃分析表明二甲双胍的作用与肿瘤分期相关，但鉴于对数据进行的有限和可变研究，应谨慎考虑。
We conducted a meta-analysis to analyse the effect of metformin on survival of pancreatic cancer patients at various stages. We performed a systematic search of PubMed, Embase, Cochrane, and Web of Science to identify all relevant studies. Summary hazard ratios (HR) of survival and 95% confidence intervals (95% CI) were calculated with a fixed or random effects model according to inter-study heterogeneity. Nine retrospective cohort studies and two randomized controlled trials (RCTs) were eligible. There was a significant improvement in survival (HR = 0.86, 95% CI 0.76–0.97; P < 0.05) in the metformin group compared with control. Subgroup analysis indicated that metformin improved survival in patients with resection (HR = 0.79, 95% CI 0.69–0.91; P < 0.05) and patients with locally advanced tumors (HR = 0.68, 95% CI 0.55–0.84; P < 0.05) but not in patients with metastatic tumors, even when RCT data were included (HR = 0.99, 95% CI 0.70–1.40; P > 0.05), or were excluded (HR = 0.89, 95% CI 0.61–1.31; P > 0.05). This meta-analysis indicated that the effect of metformin does correlate with tumor stage but should be prudently considered given the limited and variable studies performed to data.
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影响因子：
4.5
作者：
Lee, Sang Hoon;Yoon, Sang Hyun;Bang, Seungmin
通讯作者：
Bang, Seungmin
DOI：
10.1016/j.urolonc.2015.05.024
发表时间：
2015-09-01
影响因子：
2.7
作者：
Nayan, Madhur;Bhindi, Bimal;Kulkarnia, Girish S.
通讯作者：
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影响因子：
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作者：
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影响因子：
45.3
作者：
Burris, HA;Moore, MJ;VanHoff, DD
通讯作者：
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影响因子：
158.5
作者：
Neoptolemos, JP;Stocken, DD;Büchler, MW
通讯作者：
Büchler, MW