Activation of the coagulation cascade in patients with leptospirosis
Activation of the coagulation cascade in patients with leptospirosis
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DOI：
10.1086/524664
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发表时间：
2008-01-15
影响因子：
11.8
通讯作者：
Day, Nicholas P.
中科院分区：
文献类型：
--
作者：
Chierakul, Wirongrong;Tientadakul, Panatsaya;Day, Nicholas P.
背景弥散性血管内凝血（DIC）在脓毒症患者中很常见。钩端螺旋体病是热带地区脓毒症的重要病因，血小板减少相关的肺出血是死亡的主要原因，但严重钩端螺旋体病的凝血功能障碍尚未得到进一步的表征。本研究的目的是评估泰国东北部钩端螺旋体病患者的凝血因子和DIC的存在。我们测量了79例经培养和/或血清学证实的钩端螺旋体病患者和33例健康泰国对照者的血浆纤维蛋白原、D-二聚体、凝血酶-抗凝血酶III复合物和凝血酶原片段1、2的浓度，并评估了DIC评分。与健康对照组相比，79例钩端螺旋体病患者的纤维蛋白原、D-二聚体、凝血酶-抗凝血酶III复合物和凝血酶原片段1、2的中位浓度显著升高（P
Background. Disseminated intravascular coagulation (DIC) is common among patients with sepsis. Leptospirosis is an important cause of sepsis in tropical areas, and pulmonary hemorrhage associated with thrombocytopenia is the major cause of death, but the coagulopathy in severe leptospirosis has not been further characterized. The aim of this study was to evaluate coagulation factors and the presence of DIC in patients with leptospirosis in northeast Thailand.Methods. We measured plasma concentrations of fibrinogen, D-dimer, thrombin-antithrombin III complexes, and prothrombin fragment 1,2 and evaluated the DIC score in 79 patients with culture-confirmed and/or serologically confirmed leptospirosis and in 33 healthy Thai control subjects.Results. The median concentrations of fibrinogen, D-dimer, thrombin-antithrombin III complexes, and prothrombin fragment 1,2 were significantly elevated in a cohort of 79 patients with leptospirosis, compared with healthy control subjects (P