Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation.
Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation.
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通过无关脐带血移植成功治疗难治性朗格汉斯细胞组织细胞增多症。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Scott Baker
中科院分区：
文献类型：
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作者：
Rajaram Nagarajan;Joseph Neglia;N. Ramsay;Scott Baker
一名2个月大的女孩因弥漫性皮疹、间质性肺炎、耳炎和淋巴结病就诊。皮肤活检证实朗格汉斯细胞组织细胞增生症的电子显微镜。在接受多个疗程的化疗后，仅获得了边际改善，并伴有进行性骨髓和肝脏受累。决定进行人类白细胞抗原相同的无关脐带血移植。移植后2年，骨髓清除郎格罕细胞组织细胞增生症，100%供体植入。对治疗反应不足和存在器官功能障碍（骨髓和肝脏）的患者预后不良，证实了进行无关脐带血移植的决定。
A 2-month-old girl presented for treatment with a diffuse rash, interstitial pneumonia, otorrhea, and lymphadenopathy. Skin biopsy confirmed Langerhans cell histocytosis by electron microscopy. After receiving multiple courses of chemotherapy, only marginal improvement was achieved, with progressive marrow and liver involvement. The decision was made to pursue a human leukocyte antigen-identical unrelated cord blood transplantation. Two years after transplant, the bone marrow was clear of Langerhans cell histocytosis and 100% donor engraftment. The poor prognosis of patients with an inadequate response to therapy and the presence of organ dysfunction (marrow and liver) substantiated the decision to pursue an unrelated cord blood transplantation.
影响因子：
20.3
作者：
J. Wagner;J. Rosenthal;R. Sweetman;X. Shu;S. Davies;N. Ramsay;P. Mcglave;L. Sender;M. Cairo
通讯作者：
J. Wagner;J. Rosenthal;R. Sweetman;X. Shu;S. Davies;N. Ramsay;P. Mcglave;L. Sender;M. Cairo
骨髓移植治疗多系统进行性朗格汉斯细胞组织细胞增多症。
影响因子：
4.8
作者：
Greinix,HT;Storb,R;Sanders,JE;Petersen,FB
通讯作者：
Petersen,FB