CASUALTIES FOLLOWING EXPOSURE TO ZINC CHLORIDE SMOKE
CASUALTIES FOLLOWING EXPOSURE TO ZINC CHLORIDE SMOKE
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接触氯化锌烟雾造成的伤亡
DOI：
10.1016/s0140-6736(45)91239-6
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发表时间：
1945
期刊：
影响因子：
--
通讯作者：
E. Evans
中科院分区：
文献类型：
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作者：
E. Evans
本文比较了人体气性坏疽局部肌肉损伤的组织学特征，并与氯离子作用下的体外人体肌肉组织学变化进行了比较。A型韦氏杆菌滤液，除了没有水肿或气体形成外，被认为是形态上相同的。有人试图根据滤液中已知或怀疑存在的酶的作用来分析这些变化，似乎这些变化是由于对细胞膜、细胞核、胶原和网状蛋白以及粘蛋白的影响，而肌原纤维没有受到影响。缺乏细胞反应主要不是由于缺血，而是滤液的细胞溶解作用，由于这些变化可以被抗毒素抑制，因此建议在证明不可能对受影响的组织进行充分的外科切除的情况下使用局部注射抗毒素。本文只是对麦克法兰和麦克伦南的观察进行了更详细的组织学证实，如果不是他们的萌芽想法和随时准备好的合作和建议就不可能写出来。我要感谢R·E·达菲特先生在准备章节时所表现出的谨慎，感谢B·阿莫斯先生为酶溶液的准备。C l.Wdchii滤液和抗毒素由The Wellcome的JW Trevan博士亲切提供
The histology of the local muscle lesion in gas-gangrene in man has been compared with the changes occurring in human muscle in vitro as the result of the action of Cl. welchii type A filtrate and are considered to be morphologically identical, save for the absence of oedema or gas formation. An attempt has been made to analyse these changes in terms of the action of the enzymes known or suspected to be present in the filtrate, and it appears that the alterations are due to effects on-cell membranes, cell nuclei, collagen and reticulin, and mucoproteins, and that the myofibril is unaffected. The lack of cellular reaction is not due primarily to the ischsemia but to the cytolytic action of the filtrate, and since these changes can be inhibited by antitoxin it is suggested that local injection of antitoxin might be used where it has proved impossible to perform an adequate surgical excision of the affected tissue.This paper is merely a more detailed histological confirmation of the observations of Macfarlane, and MacLennan, and had it not been for their germinal idea and ready collaboration and advice could not have been written. I would wish to thank Mr. R. E. Duffett for the care he showed in preparing the sections and Mr. B. Amos for the preparation of the enzyme solutions. The Cl. wdchii filtrate and antitoxin were kindly provided by Dr. JW Trevan of the Wellcome