Modeling fibrin aggregation in blood flow with discrete-particles
Modeling fibrin aggregation in blood flow with discrete-particles
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DOI：
10.1016/j.cmpb.2004.02.001
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发表时间：
2004-09-01
影响因子：
6.1
通讯作者：
Yuen, DA
中科院分区：
文献类型：
--
作者：
Boryczko, K;Dzwinel, W;Yuen, DA
过多的凝血会导致大面积毛细血管出血。用流体粒子模型研究了凝血的介观动力学。我们假设血浆由含有纤维蛋白单体的流体颗粒组成，而红细胞和毛细血管壁则用“固体”颗粒的弹性网格来建模。流体粒子之间的相互作用产生一种短程的排斥性耗散力。含有纤维蛋白单体的颗粒具有双重性质。纤维蛋白单体聚合成水合纤维蛋白的过程是由流体颗粒之间的相互作用从排斥力转变为引力来模拟的。这个过程发生的概率是局部密度的递增函数。我们研究了长约100微米、直径约10微米的微细毛细血管中的血流。我们表明聚合模型清楚地反映了纤维蛋白在凝血中的作用。由于高加速度引起的密度波动，纤维蛋白链在很短的时间内（0.5 ms）产生。纤维蛋白的聚集改变了血液的流变特性，减缓了血液初期的流动，并捕获了红细胞，从而形成了危险的血块。2004爱思唯尔爱尔兰有限公司版权所有。
Excessive clotting can cause bleeding over a vast capillary area. We study the mesoscopic dynamics of clotting by using the fluid particle model. We assume that the plasma consists of fluid particles containing fibrin monomers, while the red blood cells and capillary walls are modeled with elastic mesh of "solid" particles. The fluid particles interact with each other with a short-ranged, repulsive dissipative force. The particles containing fibrin monomers have a dual character. The polymerization of fibrin monomers into hydrated fibrins is modeled by the change of the interactions between fluid particles from repulsive to attractive forces. This process occurs with a probability being an increasing function of the local density. We study the blood flow in microscopic capillary vessels about 100 [mum long and with diameters in order of 10 mum. We show that the model of polymerization reflects clearly the role played by fibrins in clotting. Due to the density fluctuations caused the by the high acceleration, the fibrin chains are produced within a very short time (0.5 ms). Fibrin aggregation modifies the rheological properties of blood, slows down the incipient flow, and entraps the red blood cells, thus forming dangerous clots. (C) 2004 Elsevier Ireland Ltd. All rights reserved.