YIELD OF UNPREDICTED BONE-MARROW RELAPSE DIAGNOSED BY ROUTINE MARROW ASPIRATION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIA A Report from the Children's Cancer Study Group
YIELD OF UNPREDICTED BONE-MARROW RELAPSE DIAGNOSED BY ROUTINE MARROW ASPIRATION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIA A Report from the Children's Cancer Study Group
复制标题
通过常规骨髓抽吸诊断患有急性淋巴细胞白血病的儿童出现意外骨髓复发的情况来自儿童癌症研究小组的报告
DOI：
10.1016/s0140-6736(84)91819-1
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. Hammond
中科院分区：
文献类型：
--
作者：
PaulC.J. Rogers;P. Coccia;S. Siegel;W. Bleyer;J. Lukens;H. Sather;D. Hammond
1466例急性淋巴细胞白血病患儿在每84天维持治疗周期结束时进行常规骨髓抽吸。常规骨髓抽吸检测到的复发根据临床体征或外周血计数能否预测进行分类。在低危、中危和高危白血病患者中，常规骨髓穿刺总发生率分别为0.4%、0.5%和0.8%，产生了不可预测的骨髓复发。19.4%的复发患者在体检或外周血计数出现任何临床复发症状之前通过常规监测骨髓穿刺检测到。预测组复发后的中位生存期明显短于未预测组，但两组的最终结局相同，95%的患者在复发后24个月内死亡。
1466 children with acute lymphoblastic leukaemia had routine bone-marrow aspiration at the end of each 84-day cycle of maintenance therapy. Relapses detected by routine bone-marrow aspiration were classified according to whether or not they could be predicted by clinical signs or peripheral blood counts. In the low-risk, moderate-risk, and high-risk leukaemic patients 0 4%, 0·5%, and 0·8%, respectively, of the total routine bone-marrow aspirations yielded an unpredicted bone-marrow relapse. 19·4% of relapses were detected by routine surveillance marrow aspirations before any clinical signs of relapse on physical examination or peripheral blood count. The median survival after relapse in the predicted group was significantly shorter than that in the unpredicted group, but the eventual outcome was the same in both groups, 95% of all patients dying within 24 months of relapse.