Gingival changes during pregnancy: III. Impact of clinical, microbiological, immunological and socio-demographic factors on gingival inflammation
Gingival changes during pregnancy: III. Impact of clinical, microbiological, immunological and socio-demographic factors on gingival inflammation
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DOI：
10.1111/j.1600-051x.2011.01800.x
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发表时间：
2012-03-01
影响因子：
6.7
通讯作者：
Bascones-Martinez, Antonio
中科院分区：
文献类型：
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作者：
Carrillo-de-Albornoz, Ana;Figuero, Elena;Bascones-Martinez, Antonio
目的：为了确定预测变量参与加剧牙龈炎症与pregnancy.Material和方法：在这个队列研究中，48名孕妇和28名非孕妇牙周炎。孕妇在妊娠早期、中期和晚期以及产后3个月进行评估，而非孕妇进行两次评估，间隔6个月。在每次访视时，进行临床[菌斑指数（PlI）和牙龈指数（GI）]、激素（唾液孕酮和雌二醇）、免疫学[龈沟液白细胞介素-1 β、白细胞介素-6、肿瘤坏死因子-α（TNF-α）和前列腺素-E-2]和微生物（牙周病原体培养）评价。统计分析进行了详尽的卡方自动相互作用检测（详尽CHAID），以分析独立的结果，以发展妊娠GI的预测价值。结果：PlI是最强的预测因子牵连在整个怀孕期间和分娩后的GI。在第二和第三孕期牙龈卟啉单胞菌的存在显着的牙龈炎症的恶化。当与非妊娠组相比，显着差异被发现在TNF-α的量和浓度，并在孕晚期特定的网站GI。结论：牙龈组织的细菌挑战，定量（PLI）和定性（窝藏牙龈卟啉单胞菌）似乎影响怀孕期间观察到的牙龈炎症的水平。
Aims: To identify predictor variables involved in exacerbated gingival inflammation associated with pregnancy.Material and Methods: In this cohort study, 48 pregnant and 28 non-pregnant women without periodontitis were included. The pregnant women were evaluated in the first, second and third trimester and at 3 months postpartum, whilst the non-pregnant women were evaluated twice, with a 6-month interval. At each visit, clinical [plaque index (PlI) and gingival index (GI)], hormonal (salivary progesterone and estradiol), immunological [gingival crevicular fluid interleukin-1 beta, interleukin-6, tumour necrosis factor-alpha (TNF-alpha) and prostaglandin-E-2] and microbiological (periodontal pathogens culture) evaluations were performed. Statistical analysis was undertaken using exhaustive chi-square automatic interaction detection (exhaustive CHAID) to analyse the predictive value of the independent outcomes to develop pregnancy GI.Results: PlI was the strongest predictor implicated in the GI throughout pregnancy and after delivery. During the second and third trimesters the presence of Porphyromonas gingivalis significantly contributed to the worsening of gingival inflammation. When compared with the non-pregnant group, significant differences were found in TNF-alpha amounts and concentrations and in the third trimester site-specific GI.Conclusions: Bacterial challenge to the gingival tissues, both quantitatively (PlI) and qualitatively (harbouring P. gingivalis) appears to affect the level of gingival inflammation observed during pregnancy.