PURINE AND PYRIMIDINE RIBONUCLEOTIDE CONTENTS OF RAT-LIVER AND HEPATOMA 3924A AND EFFECT OF ISCHEMIA
PURINE AND PYRIMIDINE RIBONUCLEOTIDE CONTENTS OF RAT-LIVER AND HEPATOMA 3924A AND EFFECT OF ISCHEMIA
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DOI：
10.1016/0024-3205(76)90098-9
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发表时间：
1976-01-01
期刊：
影响因子：
6.1
通讯作者：
WEBER, G
中科院分区：
文献类型：
--
作者：
JACKSON, RC;BORITZKI, TJ;WEBER, G
15个核糖核苷酸的浓度进行了测定，在冷冻夹大鼠肝脏和快速生长的肝癌3924A。肝癌组织中CTP含量大于肝组织浓度的500%，GMP含量为肝组织浓度的300%。肝细胞瘤中ATP减少（肝脏浓度的43%）。其他核苷酸显示出较小的差异。在肝脏中，10分钟的缺血导致76%的ATP损失，而AMP增加。在此期间，总腺嘌呤核糖核苷酸减少，损失是由IMP的形成，增加了75倍。GTP和CTP水平也下降，缺血肝脏，但UTP保持不变。肝癌能够维持三磷酸核糖核苷浓度在缺血。
Concentrations of 15 ribonucleotides were measured in freeze-clamped rat liver and rapidly growing hepatoma 3924A. The CTP content of the hepatoma was more than 500% of the liver concentration and GMP was 300% of the liver value. ATP was decreased in the hepatoma (43% of liver concentration). Other nucleotides showed smaller differences. In liver, 10 min of ischemia resulted in loss of 76% of the ATP, while AMP increased. Total adenine ribonucleotides decreased over this period, and the loss was accounted for by formation of IMP, which increased 75-fold. GTP and CTP levels also decreased in ischemic liver, but UTP remained constant. The hepatoma was able to maintain ribonucleoside triphosphate concentrations in ischemia.