Dysregulation of Wnt/β-catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application.
Dysregulation of Wnt/β-catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application.
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肝细胞癌中蛋白激酶Wnt/β-catenin信号传导失调及其治疗应用
DOI：
10.1111/cas.14861
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发表时间：
2021-05
期刊：
影响因子：
5.7
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Li Q;Sun M;Wang M;Feng M;Yang F;Li L;Zhao J;Chang C;Dong H;Xie T;Chen J
Wnt/β -连环蛋白信号在许多生物过程中是不可或缺的，包括胚胎发育、细胞周期、炎症和癌变。Wnt/β -连环蛋白信号的异常激活可以促进肝细胞癌（HCC）的致瘤性并增强转移潜力。靶向这一途径为HCC的精准治疗提供了新的机遇。然而，由于缺乏特异性抑制剂和该通路的复杂性，单独抑制Wnt/β‐catenin信号传导不太可能显著改善HCC患者的预后。与其他疗法联合将是提高Wnt/β‐catenin信号抑制剂疗效的重要下一步。蛋白激酶在Wnt/β - catenin信号传导中起着关键的进化保守作用，并已成为癌症治疗中最重要的药物靶点之一。靶向Wnt/β -连环蛋白信号及其调控激酶将是一种很有前途的HCC治疗策略。在这篇综述中，我们总结了肝癌中调节Wnt/β - catenin信号传导的激酶，并简要讨论了它们的分子机制。此外，我们列出了一些靶向激酶并可能抑制Wnt/β‐catenin信号传导的小分子，为临床前和临床HCC研究提供了新的视角。在这篇综述中，我们总结了肝癌中调节Wnt/β - catenin信号传导的激酶，并简要讨论了它们的分子机制。此外，我们列出了一些靶向激酶并可能抑制Wnt/β‐catenin信号传导的小分子，为临床前和临床HCC研究提供了新的视角。
Wnt/β‐catenin signaling is indispensable for many biological processes, including embryonic development, cell cycle, inflammation, and carcinogenesis. Aberrant activation of the Wnt/β‐catenin signaling can promote tumorigenicity and enhance metastatic potential in hepatocellular carcinoma (HCC). Targeting this pathway is a new opportunity for precise medicine for HCC. However, inhibiting Wnt/β‐catenin signaling alone is unlikely to significantly improve HCC patient outcome due to the lack of specific inhibitors and the complexity of this pathway. Combination with other therapies will be an important next step in improving the efficacy of Wnt/β‐catenin signaling inhibitors. Protein kinases play a key and evolutionarily conserved role in the Wnt/β‐catenin signaling and have become one of the most important drug targets in cancer. Targeting Wnt/β‐catenin signaling and its regulatory kinase together will be a promising HCC management strategy. In this review, we summarize the kinases that modulate the Wnt/β‐catenin signaling in HCC and briefly discuss their molecular mechanisms. Furthermore, we list some small molecules that target the kinases and may inhibit Wnt/β‐catenin signaling, to offer new perspectives for preclinical and clinical HCC studies. In this review, we summarize the kinases that modulate the Wnt/β‐catenin signaling in HCC and briefly discuss their molecular mechanisms. Furthermore, we list some small molecules that target the kinases and may inhibit Wnt/β‐catenin signaling to offer new perspectives for preclinical and clinical HCC studies.
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DOI：
10.3390/ph10010018
发表时间：
2017-01-28
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Chua MM;Ortega CE;Sheikh A;Lee M;Abdul-Rassoul H;Hartshorn KL;Dominguez I
通讯作者：
Dominguez I
DOI：
10.1073/pnas.1608783113
发表时间：
2016-08-16
影响因子：
11.1
作者：
Cervenka, Igor;Valnohova, Jana;Bryja, Vitezslav
通讯作者：
Bryja, Vitezslav
影响因子：
24.5
作者：
Chen J;Rajasekaran M;Xia H;Zhang X;Kong SN;Sekar K;Seshachalam VP;Deivasigamani A;Goh BK;Ooi LL;Hong W;Hui KM
通讯作者：
Hui KM
PTK2通过激活Wnt/β-连环蛋白信号传导促进肝细胞癌中的癌症干细胞特征
影响因子：
9.7
作者：
Fan, Zhongyi;Duan, Jingjing;Xu, Xiaojie
通讯作者：
Xu, Xiaojie
影响因子：
11.8
作者：
Davidson, Gary;Shen, Jinlong;Niehrs, Christof
通讯作者：
Niehrs, Christof