Diagnosis, management, and treatment of hepatitis C: an update.

Diagnosis, management, and treatment of hepatitis C: an update.
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DOI:
10.1002/hep.22759
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发表时间:
2009-04
期刊:
Hepatology (Baltimore, Md.)
影响因子:
--
通讯作者:
American Association for the Study of Liver Diseases
American Association for the Study of Liver Diseases
中科院分区:
其他
文献类型:
--
作者:
Ghany MG;Strader DB;Thomas DL;Seeff LB;American Association for the Study of Liver Diseases

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背景丙型肝炎病毒是一种主要的公共卫生问题,也是慢性肝病的主要病因。据估计,全球有1.8亿人受到感染。6在美国,1999至2002年间丙型肝炎病毒感染率为1.6%,相当于约410万丙型肝炎抗体(抗-丙型肝炎病毒)阳性者,其中80%估计为病毒携带者。7丙型肝炎是美国肝脏疾病的主要死因和肝移植的主要适应症8一些计算表明,与丙型肝炎病毒感染有关的死亡率(死于肝功能衰竭或肝细胞癌)在未来20年将继续上升。9本文件的目的是为临床医生提供预防、诊断和管理丙型肝炎病毒感染的循证方法。
BackgroundThe hepatitis C virus (HCV) is a major public health problem and a leading cause of chronic liver disease. 5 An estimated 180 million people are infected worldwide. 6 In the United States (US), the prevalence of HCV infection between the years 1999 and 2002 was 1.6%, equating to about 4.1 million persons positive for antibody to hepatitis C (anti-HCV), 80% of whom are estimated to be viremic. 7 Hepatitis C is the principal cause of death from liver disease and the leading indication for liver transplantation in the US 8 Some calculations suggest that mortality related to HCV infection (death from liver failure or hepatocellular carcinoma) will continue to increase over the next two decades. 9 The purpose of this document is to provide clinicians with evidence-based approaches to the prevention, diagnosis, and management of HCV infection.
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