Cholesterol-lowering effect of dietary Lupinus angustifolius proteins in adult rats through regulation of genes involved in cholesterol homeostasis
Cholesterol-lowering effect of dietary Lupinus angustifolius proteins in adult rats through regulation of genes involved in cholesterol homeostasis
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DOI：
10.1016/j.foodchem.2011.12.004
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发表时间：
2012-06-01
期刊：
影响因子：
8.8
通讯作者：
Chiesa, Giulia
中科院分区：
文献类型：
--
作者：
Parolini, Cinzia;Rigamonti, Elena;Chiesa, Giulia
在之前的研究没有明确的适应症的情况下，一项大鼠研究旨在评估狭叶羽扇豆蛋白(蓝色羽扇豆蛋白)可能的降血脂作用。用Nath的高胆固醇饲料喂养大鼠28天，饲料中含有20%的酪蛋白或蓝羽扇豆蛋白。在饮食治疗14天和28天后，蓝羽扇豆喂养的大鼠的血浆总胆固醇水平显著低于酪蛋白喂养的大鼠(分别为-53.0%和-55.3%，p<；0.0005)。相反，两组之间的甘油三酯和高密度脂蛋白-胆固醇水平没有显著差异。饲喂羽扇豆蛋白的大鼠肝脏中SREBP-2和胆汁酸生物合成的限速酶CYP7A1的mRNA水平较高(p
In the absence of a clear indication from previous studies, a rat study was designed to evaluate a possible hypolipidaemic effect of Lupinus angustifolius (blue lupin) proteins. Rats were fed for 28 days Nath's hypercholesterolaemic diets containing 20% casein or blue lupin proteins. After 14 and 28 days of dietary treatment, blue-lupin-fed rats had markedly lower plasma total cholesterol levels than rats fed casein (-53.0% and -55.3%, respectively, p < 0.0005). No significant differences were instead observed for triglyceride and HDL-cholesterol levels between the two groups. Lupin-protein-fed rats displayed higher hepatic mRNA levels of SREBP-2, a major transcriptional regulator of intracellular cholesterol levels, and CYP7A1, the rate-limiting enzyme in bile acid biosynthesis (p