Comparison of Frequencies of Patent Foramen Ovate and Thoracic Aortic Atherosclerosis in Patients With Cryptogenic Ischemic Stroke Undergoing Transesophageal Echocardiography
Comparison of Frequencies of Patent Foramen Ovate and Thoracic Aortic Atherosclerosis in Patients With Cryptogenic Ischemic Stroke Undergoing Transesophageal Echocardiography
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DOI：
10.1016/j.amjcard.2011.07.058
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发表时间：
2011-12-15
影响因子：
2.8
通讯作者：
Nixon, J. V. (Ian)
中科院分区：
文献类型：
--
作者：
Gu, Xiaoyan;He, Yihua;Nixon, J. V. (Ian)
研究表明，年龄≥ 55岁的患者中存在卵圆孔未闭（PFO）和隐源性卒中（CS）之间存在相关性。本研究的目的是确定CS在2个年龄组与PFO和动脉粥样硬化斑块在升主动脉和主动脉弓。经食管超声心动图在229例患者评价CS进行了比较，在314例患者评价心脏疾病以外的PFO，没有中风的历史（对照组）。在所有患者中测定PFO的患病率和升主动脉和主动脉弓中复杂动脉粥样硬化斑块的存在，并在2个年龄组的CS和对照患者之间进行比较。在年龄≥ 55岁的CS患者中，PFO的患病率显著高于对照组患者（28/115 [24%] vs 21/143 [15%]，p = 0.049）。无论患者年龄如何，两组房间隔瘤的发生率相似，复杂动脉粥样硬化斑块的患病率也相似。多变量分析显示PFO与CS独立相关，与患者年龄无关（≥ 55岁：比值比1.9，95%置信区间1.1 - 3.5，p = 0.03）。总之，PFO与年轻（年龄= 55岁）患者的CS显著相关。房间隔动脉瘤和升主动脉和主动脉弓的复杂动脉粥样硬化似乎与CS无关。(C)2011年由Elsevier Inc.出版(Am J Cardiol 2011;108：1815-1819）
Studies have shown an association between the presence of a patent foramen ovate (PFO) and cryptogenic stroke (CS) in patients aged = 55 years. The aim of this study was to determine the association of CS in the 2 age groups with PFO and with atheromatous plaques in the ascending aorta and in the aortic arch. Transesophageal echocardiograms in 229 patients evaluated for CS were compared to those in 314 patients evaluated for cardiac disease other than PFO with no histories of stroke (the control group). The prevalence of PFO and the presence of complex atheromatous plaques in the ascending aorta and aortic arch were determined in all patients and compared between the CS and control patients in the 2 age groups. The prevalence of PFO was significantly higher in patients with CS than in control patients among those aged = 55 years (28 of 115 [24%] vs 21 of 143 [15%], p = 0.049). The incidence of atrial septal aneurysm was similar in the 2 groups irrespective of patient age, as was the prevalence of complex atheromatous plaques. Multivariate analysis showed that PFO was independently associated with CS, irrespective of patient age (= 55 years: odds ratio 1.9, 95% confidence interval 1.1 to 3.5, p = 0.03). In conclusion, PFO was significantly associated with CS in younger (aged = 55 years) patients. Atrial septal aneurysm and complex atheromas in the ascending aorta and aortic arch do not appear to be associated with CS. (C) 2011 Published by Elsevier Inc. (Am J Cardiol 2011;108:1815-1819)