Drug discrimination analysis of pseudoephedrine in rats
Drug discrimination analysis of pseudoephedrine in rats
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DOI：
10.1016/s0091-3057(97)00459-0
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发表时间：
1998-02-01
影响因子：
3.6
通讯作者：
Baldwin, BA
中科院分区：
文献类型：
--
作者：
Tongjaroenbuangam, W;Meksuriyen, D;Baldwin, BA
以大鼠为实验对象，通过两级操作性药物鉴别实验，训练大鼠对1 mg/kg苯丙胺类药物和生理盐水类药物进行区分。伪麻黄碱（一种具有中枢和外周作用的拟交感神经药物）在剂量为10 mg/kg时未能替代安非他明，在剂量为20 mg/kg时出现部分替代，而在剂量为40 mg/kg时出现完全替代。在训练剂量（1mg /kg）下，苯肾上腺素（0.2 ~ 0.8 mg/kg）不能替代安非他明，这表明了苯丙胺信号的特异性。讨论了高剂量伪麻黄碱滥用的可能性。(C) 1998爱思唯尔科学有限公司
Rats were trained to discriminate amphetamine, 1 mg/kg given intraperitoneally, from saline injection in a two-lever operant drug discrimination task. Pseudoephedrine (a sympathomimetic drug with central and peripheral actions) at doses of 10 mg/kg failed to substitute for amphetamine, at 20 mg/kg partial substitution occurred, while at a 40 mg/kg full substitution was seen. The specificity of the amphetamine cue at the training dose used (1 mg/kg) was shown by the finding that a peripherally acting sympathomimetic drug phenylephrine at doses from 0.2 to 0.8 mg/kg failed to substitute for amphetamine. The potential for abuse of pseudoephedrine administered at high doses is discussed. (C) 1998 Elsevier Science Inc.