An elastic analysis of Listeria monocytogenes propulsion
An elastic analysis of Listeria monocytogenes propulsion
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DOI：
10.1016/s0006-3495(00)76473-3
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发表时间：
2000-11-01
影响因子：
3.4
通讯作者：
Prost, J
中科院分区：
文献类型：
--
作者：
Gerbal, F;Chaikin, P;Prost, J
单核细胞增生李斯特菌利用肌动蛋白聚合的能量推动自己穿过感染的组织。在稳定状态下，它不断地在其表面添加新的聚合细丝，推动它的尾巴，这是由先前交联的肌动蛋白细丝制成的。在本文中，我们介绍了一个弹性模型来描述如何添加肌动蛋白丝的尾巴的结果在细菌上的推进力。在细菌表面生长的丝状体产生应力，当细菌向前移动时，应力在细菌的后部得到缓解。该模型导致细菌从侧面生长和从背面生长之间的自然竞争，每种生长都具有不同的速度和强度。这种竞争可以导致在李斯特菌突变体中观察到的周期性运动。
The bacterium Listeria monocytogenes uses the energy of the actin polymerization to propel itself through infected tissues. In steady state, it continuously adds new polymerized filaments to its surface, pushing on its tail, which is made from previously cross-linked actin filaments. In this paper we introduce an elastic model to describe how the addition of actin filaments to the tail results in the propulsive force on the bacterium. Filament growth on the bacterial surface produces stresses that are relieved at the back of the bacterium as it moves forward. The model leads to a natural competition between growth from the sides and growth from the back of the bacterium, with different velocities and strengths for each. This competition can lead to the periodic motion observed in a Listeria mutant.