Risk of Parkinson's Disease in the Users of Antihypertensive Agents: An Evidence from the Meta-Analysis of Observational Studies.
Risk of Parkinson's Disease in the Users of Antihypertensive Agents: An Evidence from the Meta-Analysis of Observational Studies.
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DOI：
10.1155/2016/5780809
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Bansal D
中科院分区：
文献类型：
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作者：
Mullapudi A;Gudala K;Boya CS;Bansal D
背景抗高血压药物已被证明可以抑制氧化应激和炎症反应，从而对帕金森病（PD）具有神经保护作用。流行病学证据表明，抗高血压药物的使用与PD风险之间存在不一致性。本研究旨在研究抗高血压药物的使用与PD风险之间的关系。方法.在PubMed、EMBASE和PsycINFO数据库中进行了文献检索，直至2012年2月，寻找评价抗高血压药物使用与PD风险之间相关性的观察性研究。在进行荟萃分析之前，对研究的发表偏倚和异质性进行了评价。使用随机效应模型（DerSimonian和Laird方法）计算合并相对风险（RR）估计值和95%置信区间（CI）。还进行了亚组分析和敏感性分析。结果纳入了7项相关研究，共包括28，32，991例受试者。抗高血压药物总体使用的汇总RR为0.95（95% CI 0.84-1.05）。在钙通道阻滞剂使用者中观察到PD风险显著降低（RR 0.82，95% CI 0.71-0.93）。异质性显著（I2 = 76.2%），但未观察到发表偏倚。结论.抗高血压药物的总体使用与PD风险无显著相关性。CCBs具有显著的保护作用。然而，需要大样本量和剂量关系的研究来加强我们的假设。
Background. Antihypertensive agents have been shown to inhibit oxidative stress and inflammatory response and thus neuroprotection in Parkinson's disease (PD). Epidemiological evidence suggests inconsistency between use of antihypertensives and risk of PD. This study is aimed to examine the association between antihypertensive use and risk of PD. Methods. Literature search in PubMed, EMBASE, and PsycINFO database was undertaken through February 2012 looking for observational studies evaluating the association between antihypertensive drug use and risk of PD. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model (DerSimonian and Laird method). Subgroup analyses and sensitivity analysis were also performed. Results. Seven relevant studies including a total of 28,32,991 subjects were included. Pooled RR of overall use of antihypertensive agents was found to be 0.95 (95% CI 0.84–1.05). A significant reduction in the risk of PD was observed among users of calcium channel blockers (RR 0.82, 95% CI 0.71–0.93). Significant heterogeneity (I 2 = 76.2%) but no publication bias was observed. Conclusions. Overall use of antihypertensive agents showed no significant association with the risk of PD. CCBs provided significant protective role. However, studies with large sample size and dose relationships are required to strengthen our hypothesis.