Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010
Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010
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DOI：
10.1136/jclinpath-2012-200797
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发表时间：
2012-08-01
影响因子：
3.4
通讯作者：
Zigeuner, Richard
中科院分区：
文献类型：
--
作者：
Pichler, Martin;Hutterer, Georg C.;Zigeuner, Richard
目的分析肾细胞癌（RCC）的阶段，等级，组织学和坏死迁移在一个大型的欧洲中心系列在过去的27 years.Methods 2739连续患者的病理报告，肾切除术，从1984年至2010年在该机构的作者进行了系统的重新评估。根据手术日期将患者分为5个时间组：第1组：1984-1989年，第2组：1990-1994年，第3组：1995-1999年，第4组：2000-2004年，第5组：2005-2010年。结果第1组和第5组分别有62/485（12.8%）和312/639（48.8%）例pT 1a小肿瘤（P
Aims To analyse renal cell carcinoma (RCC) stage, grade, histology and necrosis migration in a large European centre series over the last 27 years.Methods The pathology reports of 2739 consecutive patients with RCC who underwent nephrectomy from 1984 to 2010 at the institution of the authors were systematically re-evaluated. Patients were pooled into five time groups according to the date of surgery: group 1: 1984-1989, group 2: 1990-1994, group 3: 1995-1999, group 4: 2000-2004 and group 5: 2005-2010, respectively. Changes in pT categories according to WHO 2010 classification, tumour grade, histological subtype and presence of tumour necrosis (TN) were evaluated.Results Small pT1a tumours were found in 62/485 (12.8%) and 312/639 (48.8%) patients in groups 1 and 5, respectively (p