Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
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DOI：
10.1038/ng1806
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发表时间：
2006-06-01
期刊：
影响因子：
30.8
通讯作者：
Panstruga, Ralph
中科院分区：
文献类型：
--
作者：
Consonni, Chiara;Humphry, Matthew E.;Panstruga, Ralph
在真菌子囊菌门中，在植物和动物中引起疾病的能力在真菌发生过程中反复获得和失去（1）。在单子叶大麦中，功能丧失的mlo等位基因导致对子囊菌Blumeria graminis f.大麦，白粉病的病原体（2，3）。然而，迄今为止，基于mlo的抗病性被认为是大麦特有的现象。在这里，我们证明了MLO蛋白在双子叶植物拟南芥白粉病发病机理的保守要求。上位性分析表明，A.拟南芥不涉及信号分子乙烯、茉莉酸或水杨酸，但需要突触融合蛋白、糖基水解酶和ABC转运蛋白（4-6）。这些发现意味着，一个共同的寄主细胞进入机制的白粉病真菌进化一次，至少2亿年前，这表明，在白粉菌（白粉病）的能力，导致疾病一直是一个稳定的性状在整个生殖系统。
In the fungal phylum Ascomycota, the ability to cause disease in plants and animals has been gained and lost repeatedly during phylogenesis(1). In monocotyledonous barley, loss-of-function mlo alleles result in effective immunity against the Ascomycete Blumeria graminis f. sp. hordei, the causal agent of powdery mildew disease(2,3). However, mlo-based disease resistance has been considered a barley-specific phenomenon to date. Here, we demonstrate a conserved requirement for MLO proteins in powdery mildew pathogenesis in the dicotyledonous plant species Arabidopsis thaliana. Epistasis analysis showed that mlo resistance in A. thaliana does not involve the signaling molecules ethylene, jasmonic acid or salicylic acid, but requires a syntaxin, glycosyl hydrolase and ABC transporter(4-6). These findings imply that a common host cell entry mechanism of powdery mildew fungi evolved once and at least 200 million years ago, suggesting that within the Erysiphales ( powdery mildews) the ability to cause disease has been a stable trait throughout phylogenesis.