Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation.
Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation.
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DOI：
10.1097/fjc.0000000000000869
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发表时间：
2020-09
影响因子：
3
通讯作者：
Webb RC
中科院分区：
文献类型：
--
作者：
Dela Justina V;Giachini FR;Sullivan JC;Webb RC
toll样受体（TLRs）在先天免疫系统中发挥着重要作用，最近，它们被证明参与调节血压。高血压的发病率在男性中较高，在绝经后的女性中也会增加。事实上，与同龄的男性相比，绝经前的女性免受心血管疾病的侵害，而且这种保护作用随着更年期的消失已经得到了充分的证实。然而，这种保护作用在女性中的分子机制尚不清楚。它是否可能与先天免疫系统的差异激活有关仍有待阐明。这篇综述的重点是(1)男性和女性在TLR激活方面的差异，(2)TLR激活是否可能以性别依赖的方式影响血压的调节。
Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood pressure. The incidence of hypertension is higher in men, and it increases in postmenopausal women. In fact, premenopausal women are protected from cardiovascular disease compared with age-matched men, and it is well established that this protective effect is lost with menopause. However, the molecular mechanisms underlying this protection in women are unknown. Whether or not it could be related to differential activation of the innate immune system remains to be elucidated. This review focuses on (1) the differences between men and women in TLR activation and (2) whether TLR activation may influence the regulation of blood pressure in a sex-dependent manner.