Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies
Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies
复制标题
DOI：
10.1158/1940-6207.capr-10-0289
复制
发表时间：
2011-05-01
影响因子：
3.3
通讯作者：
Ma, Jing
中科院分区：
文献类型：
--
作者：
Lee, Jung Eun;Li, Haojie;Ma, Jing
目前尚不清楚低水平维生素D是否会增加患结肠癌和/或直肠癌的风险。为了研究循环维生素D水平与结肠癌和直肠癌之间的关系，我们在医师健康研究中检查了25-羟基维生素D [25(OH)D]和1,25-二羟基维生素D [1,25(OH)2D]血浆水平与结肠癌和直肠癌之间的关系，然后对包括医师健康研究在内的8项循环25(OH)D水平与结肠癌和直肠癌的前瞻性研究进行了荟萃分析。使用随机效应模型汇总研究特异性or和95% ci。这项荟萃分析共纳入了1822例结肠癌和868例直肠癌。我们观察到与结直肠癌的显著负相关（OR = 0.66; 95% Cl, 0.54-0.81），比较循环25(OH)D水平的上分位数与下分位数。与结肠癌（OR = 0.77; 95% CI, 0.56-1.07；结肠和直肠癌之间差异的P值= 0.20）相比，直肠癌（上分位数与下分位数OR = 0.50; 95% CI, 0.28-0.88）的负相关更强。这些数据表明，循环25(OH)D水平与结直肠癌呈负相关，与直肠癌的相关性更强。巨蟹码头；4 (5);735 - 43。(c) 2011年AACR。
It remains unknown whether increased risk with low levels of vitamin D is present for colon and/or rectal cancer. To investigate the association between circulating vitamin D levels and colon and rectal cancer, we examined the associations between plasma levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and colon and rectal cancer in the Physicians' Health Study and then conducted a meta-analysis of eight prospective studies of circulating levels of 25(OH)D and colon and rectal cancers, including the Physicians' Health Study. Study-specific ORs and 95% CIs were pooled by using a random-effects model. A total of 1,822 colon and 868 rectal cancers were included in the meta-analysis. We observed a significant inverse association for colorectal cancer (OR = 0.66; 95% Cl, 0.54-0.81), comparing top versus bottom quantiles of circulating 25(OH)D levels. The inverse association stronger for rectal cancer (OR = 0.50 for top versus bottom quantiles; 95% CI, 0.28-0.88) than colon cancer (OR = 0.77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer. Cancer Pier Res; 4(5); 735-43. (c) 2011 AACR.